Prognosis of Hematological Cancer Patient Underwent Mechanical Ventillation

Completed

• Conditions: Hematological Malignancy; Acute Respiratory Failure; Mechanical Ventilation
• Interventions: Procedure: Mechanical ventilation

• Registration Number: NCT02562105
• Lead Sponsor: Mansoura University

Brief Summary

This observational cohort aimed to re-evaluate the outcome of hematologic cancer patients admitted to the intensive care unit of Mansoura oncology center through a cohort study as regards their need for mechanical ventilation during two years.

Detailed Description

It has been believed for many years that the scene of cancer patients requiring mechanical ventilation is frustrating. The needed life support measures drain much of health resources and add a significant burden on the patient's family. Many factors have been responsible for the high mortality rates among hematologic cancer patients admitted to intensive care unit. Among of these factors, the invasive treatments that are frequently employed in today's intensive care unit. These procedures give chance for development of severe infection and multiple organ failure which are common events in immune-compromised patients (e.g. neutropenia) and in those exposed to chemotherapy. The most common form of organ failure in those patients is acute respiratory failure which is a major predictor of mortality in that population. The prognosis of such failure may vary depending on its causes and severity, co morbidity, associated acute organ failure and characters of the underlying malignancy. After the recent advances in the field of intensive care and shedding light on the benefits of the noninvasive ventilation in immune-compromised patients, the overall survival rate of cancer patients admitted to intensive care unit are improving.

Study Timeline

• Study Start: 2015-01
• Primary Completion: 2015-08
• Status Verified: 2015-09
• Study Completion: 2015-09
• Study First Submitted: 2015-09-23
• Study First Submitted QC: 2015-09-27
• Last Update Submitted: 2015-09-27
• Study First Posted: 2015-09-29
• Last Update Posted: 2015-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Critical ill hematological cancer patient
• Requiring mechanical ventilation

Exclusion Criteria

• Patients with acute coronary syndrome.
• Patients with cancer remission more than 5 years.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mechanical ventilation	Mechanical ventilation	requiring mechanical ventilation at admission to ICU for one day or more during the study period

Primary Outcome Measures

Name	Time	Method
Survival	through study completion, an average of 30 days after admission to intensive care unit	Continuing to live

Secondary Outcome Measures

Name	Time	Method
Sequential Organ Failure Assessment score	up to 24 hours after admission to the intensive care unit	Sequential Organ Failure Assessment (SOFA) Score
lowest Pa02/FiO2	up to 24 hours after admission to the intensive care unit	PaO2 "arterial oxygen tension"/FiO2 "inspired fraction of oxygen" ratio
Simplified Acute Physiology Score II	up to 24 hours after admission to the intensive care unit	Simplified Acute Physiology Score (SAPS II)
Reason for need of ventilatory support	up to 24 hours after admission to the intensive care unit	Advanced malignancy, respiratory muscle weakness, respiratory failure, lung metastasis, coma, sepsis, multi-organs failure
Mode of mechanical ventilation	up to 24 hours after admission to the intensive care unit	synchronised intermittent, pressure-controlled, volume-controlled, pressure support, continuous positive airway pressure, volume guarantee, adjusted pressure release ventilation, or adaptive proportional assist ventilation

Trial Locations

Locations (1)

Mansoura Cancer Therapy Center; 🇪🇬 Mansoura, Dakahlia, Egypt