Therapeutic efficacy of home-based long-term cerebellar transcranial direct current stimulation on cerebellar ataxia

Not Applicable

• Conditions: Diseases of the nervous system

• Registration Number: KCT0006626
• Lead Sponsor: Bundang CHA General Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 5 October 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

1. Age ranging from 30 to 69 years old
2. Patients with cerebellar ataxia, diagnosed as multisystem atrophy-cerebellar type, spinocerebellar ataxia, idiopathic late onset cerebellar ataxia
3. K-MMSE >=24
4. Unassisted gait (for more than 10 m)
5. Voluntarily signed up for the clinical trial

Exclusion Criteria

1. Presence of medical or neurological disorders, or head trauma history
2. Presence of cognitive dysfunction affecting the ability to understand informed consent or perform the clinical trial
3. Presence of any suicidal idea or psychiatric disorders
4. Contraindication for tDCS (e.g. metallic device inserted in head)
5. Presence of skin problem hindering electrode adherence
6. Possibility of pregnancy
7. Pregnant state
8. Other reasons that are considered unsuitable for study enrollment

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
International Cooperative Ataxia Rating Scale (ICARS)

Secondary Outcome Measures

Name	Time	Method
temporospatial parameters from GAITRite/Pedoscan;Montreal Cognitive Assessment/Korean Cerebellar Cognitive Affective/Schmahmann Syndrome scale (MoCA/K-CCAS);Beck Depression Inventory/Beck Anxiety Inventory (BDI/BAI);connectivity/integrity parameters from functional MR/diffusion tensor image;after-effect of tDCS (ICARS, GAITRite/Pedoscan, MoCA/K-CCAS, BAI/BDI);safety evaluation (adverse event)