Blood Pressure Lowering Effect of Supplementation With Korea Red Ginseng Associated With Reductions in Circulating Lp-PLA2 Activity and Lysophospatidylcholines and an Increase in Dihydrobiopterin in Prehypertensive Subjects
Phase 3
Completed
- Conditions
- Prehypertension
- Registration Number
- NCT02326766
- Lead Sponsor
- Yonsei University
- Brief Summary
This study evaluated effects of red ginseng consumption on blood pressure (BP) and fasting plasma metabolomes.
- Detailed Description
A randomized, double-blind, placebo-controlled study was conducted on nonobese, nondiabetic and prehypertensive subjects. Over a 12 week test period, the red ginseng group (n=31) consumed 10 capsules (total 5g) daily containing red ginseng, while the placebo group (n=31) consumed the same product without red ginseng. Fasting plasma metabolomes were profiled using UPLC-LTQ-Orbitrap mass spectrometry.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- nondiabetic, nonobese and prehypertensive subjects with blood pressures ranging 120 - 139 mmHg (systolic) or 80-89 mmHg (diastolic) were enrolled in this study.
Exclusion Criteria
- exclusion criteria included previous diagnosed clinical hypertension
- self-reported use of antihypertensive medication
- abnormal liver or renal function
- history of cardiovascular disease
- kidney disease
- cancer
- thyroid or pituitary disease or any other serious life-threatening illness that required regular medical treatment
- we also excluded women who were pregnant, breast feeding or intending to become pregnant during the time of study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method changes from baselilne in blood pressure 12 week
- Secondary Outcome Measures
Name Time Method changes from baseline in plasma metabolites 12 week