NCT02326766已完成3 期
Blood Pressure Lowering Effect of Supplementation With Korea Red Ginseng Associated With Reductions in Circulating Lp-PLA2 Activity and Lysophospatidylcholines and an Increase in Dihydrobiopterin in Prehypertensive Subjects
适应症
干预措施
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 62
- 主要终点
- changes from baselilne in blood pressure
研究概览
简要总结
This study evaluated effects of red ginseng consumption on blood pressure (BP) and fasting plasma metabolomes.
详细描述
A randomized, double-blind, placebo-controlled study was conducted on nonobese, nondiabetic and prehypertensive subjects. Over a 12 week test period, the red ginseng group (n=31) consumed 10 capsules (total 5g) daily containing red ginseng, while the placebo group (n=31) consumed the same product without red ginseng. Fasting plasma metabolomes were profiled using UPLC-LTQ-Orbitrap mass spectrometry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •nondiabetic, nonobese and prehypertensive subjects with blood pressures ranging 120 - 139 mmHg (systolic) or 80-89 mmHg (diastolic) were enrolled in this study.
排除标准
- •exclusion criteria included previous diagnosed clinical hypertension
- •self-reported use of antihypertensive medication
- •abnormal liver or renal function
- •history of cardiovascular disease
- •kidney disease
- •thyroid or pituitary disease or any other serious life-threatening illness that required regular medical treatment
- •we also excluded women who were pregnant, breast feeding or intending to become pregnant during the time of study.
研究组 & 干预措施
KRG
Experimental
5g Korea red ginseng (KRG)
干预措施: KRG (Dietary Supplement)
Placebo
Placebo Comparator
5 g placebo (corn starch)
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
changes from baselilne in blood pressure
时间窗: 12 week
次要结局
- changes from baseline in plasma metabolites(12 week)
研究者
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