Study on the effect of rifaximin on cirrhosis
Not Applicable
- Conditions
- Hepatic encephalopathy (Overt encephalopathy, Covert encephalopathy) Hyperammonemia
- Registration Number
- JPRN-UMIN000044146
- Lead Sponsor
- Hokkaido University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Not provided
Exclusion Criteria
1.Persons with pulmonary tuberculosis and other tuberculosis 2.Those who are pregnant or breastfeeding 3.Those who have been diagnosed with pseudomembranous enteritis 4.Others who are judged by the principal investigator or coordinator to be inappropriate as research subjects
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in ammonia levels due to rifaximin administration
- Secondary Outcome Measures
Name Time Method 1.Changes in hepatic encephalopathy symptoms before and after administration of rifaximin 2.Changes in NP-test test results before and after administration of rifaximin 3.Changes in bacterial translocation markers before and after administration of rifaximin 4.Changes in muscle mass before and after administration of rifaximin 5.Changes in fecal bacterial flora before and after administration of rifaximin 6.Correlation between ammonia value, various blood test values, and NP-test results 7.Correlation between ammonia value and bacterial translocation marker 8.Correlation between ammonia level and endotoxin and preceptin 9.Relationship between ammonia level and fecal bacterial flora