Total Parathyroidectomy With Autotransplantation Versus Total Parathyroidectomy Alone for Secondary Hyperparathyroidism
- Conditions
- Secondary Hyperparathyroidism;Parathyroidectomy
- Interventions
- Procedure: Parathyroidectomy
- Registration Number
- NCT04922892
- Lead Sponsor
- The Second Hospital of Nanjing Medical University
- Brief Summary
Total parathyroidectomy with autotransplantation (TPTX+AT) and Total parathyr- oidectomy alone (TPTX) are the common surgical procedures.The purpose of the study was to compare the long-term benefits of surgery between the two groups.
- Detailed Description
The trial was performed as a nonconfirmatory randomized controlled pilot trial with 200 patients on long-term dialysis with otherwise uncontrollable SHPT to generate data on the rate of recurrent disease within a 5-year follow-up period after TPTX or TPTX+AT. Parathyroid hormone (PTH) and calcium levels, recurrent or persistent hyperparathyroidism, parathyroid reoperations, morbidity, and mortality were evaluated during a 5-year follow-up.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
Severe renal secondary hyperparathyroidism
Patients with diabetes a history of chronic inflammatory disease a history of malignant tumor a history of kidney transplantation a history of neck surgery a history of alcohol abuse a history of drug abuse inability to cooperate with the participants refusal to participate in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Total Parathyroidectomy With Autotransplantation Parathyroidectomy Total Parathyroidectomy With Autotransplantation Total Parathyroidectomy Alone Parathyroidectomy Total Parathyroidectomy Alone , without autotransplantation
- Primary Outcome Measures
Name Time Method the rate of recurrent 60 months the rate of recurrent
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
NanjingMU
🇨🇳Nanjing, China