Investigation of the effects and mechanisms of action of different wavelengths of ultraviolet B (UVB) radiation in the treatment of psoriasis

Not Applicable

Completed

• Conditions: Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology; Skin and Connective Tissue Diseases; Psoriasis

• Registration Number: ISRCTN43688684
• Lead Sponsor: ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2010-04-30
• Study Start: 2010-05-12
• Last Update Posted: 6 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

1. Aged 18 years and over, with no sex specific criteria
2. All patients who are prescribed routine UVB (TL01) for their psoriasis at our centre
3. Give informed consent to participate

Exclusion Criteria

1. Aged under 18 years
2. Systemic immunosupression within 3 months
3. UVB exposure to lower back within 3 months of recruitment
4. Topical treatments other than emollients for 2 weeks

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Whether the number of apoptotic cells seen within the epidermis is sufficient to allow plaque remodelling. Measured up to 48 hours (4 hours, 8 hours, 12 hours,15 hours, 18 hours, 24 hours, and 48 hours).

Secondary Outcome Measures

Name	Time	Method
<br> 1. Effect of skin type<br> 2. UV dose<br> 3. Age and gender<br><br> Measured up to 48 hours (4 hours, 8 hours, 12 hours,15 hours, 18 hours, 24 hours, and 48 hours).<br>