Role of adrenaline in the inflammatory response in people with diabetes mellitus type 1, and healthy individuals - Adrenaline induced inflammation

Radboud Universitair Medisch Centrum0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月9日

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•Ability to provide written informed consent Body-Mass Index: 19-30 kg/m2 Age >=16 years, <= 75 years Blood pressure: <140/90 mmHg Non-smoking Electrocardiogram not showing any serious arrythmia*s (PVC*s and PAC*s accepted)

•Any event of cardiovascular disease in the past 5 years (e.g. myocardial infarction, stroke, heart failure, symptomatic peripheral arterial disease) Pregnancy or breastfeeding or unwillingness to undertake birth control measures Epilepsy, Current treatment with Alpha or beta blockers ( doxazosin, propranolol) History of panic disorders History of Arrhythmias Use of immune-modifying drugs or antibiotics Use of tricyclic antidepressants or MAO inhibitors Use of statins (e.g. stop statins >2 weeks before performing blood sampling. Any infection with systemic symptoms in past 2 weeks Vaccination in the past 2 weeks Proliferative retinopathy Nephropathy with an estimated glomerular filtration rate (by MDRD) *60ml/min/1.73m2 Overt impaired hypoglycaemic awareness assed by the Clarke Questionnaire 4 or highe

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