Fish oil and hip fracture

Phase 1

Recruiting

• Conditions: Elderly hip fracture patients with malnutrition; Diet and Nutrition - Other diet and nutrition disorders; Injuries and Accidents - Fractures

• Registration Number: ACTRN12608000099325
• Lead Sponsor: Dr Michelle Miller

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-02-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

60 years or over
Hip fracture sufferers
No cognitive impairment according to the Mini Mental State Examination (MMSE score over 24/30)
At risk of subsequent weight loss according to the Simplified Nutrition Appetite Questionnaire (SNAQ score less than or =14/20)
Elevated CRP (6mg/L or more)
Able to consent

Exclusion Criteria

Allergy to fish
Initiation of anti-inflammatory corticosteroids within the prior two weeks
Ingestion of n-3 fatty acid supplements within four weeks of study initiation
Life expectancy less than 6 weeks

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percent weight change[At 6 weeks];Levels of inflammatory markers as follows, measured by blood test:<br>1 C-reactive protein (CRP) <br>2 Tumour necrosis factor alpha (TNF-alpha)<br>3 Interleukin 1 beta (IL-1beta)<br>4 Interleukin 6 (IL-6)[At 6 weeks]

Secondary Outcome Measures

Name	Time	Method
evels of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) in erythrocyte membrane, measured by blood test[At 6 weeks];Body composition, assessed by bioelectrical impedance analysis (BIA)[At 6 weeks]