Serum BDNF Role as a Biomarker for Stroke Rehabilitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Serum BDNF
研究概览
简要总结
This study aims to develop the quantitative biomarker to establish the individualized strategy in stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) acts on certain neurons of the central nervous system (CNS) helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. BDNF in CNS can be assessed by analysing serum BDNF. The final objective of this study is to demonstrate a role of biomarker of BDNF in stroke rehabilitation to establish the individualized strategy.
详细描述
Serum BDNF, proBDNF and MMP-9 in all participants will be measured before and after the comprehensive inpatient rehabilitation during subacute stroke phase. At 3 months after stroke onset, serum BDNF, proBDNF and MMP-9 will also be measured.
In addition, motor impairment with Fugl-Meyer assessement will be assessed at same time points with serum analysis.
We will compare potential serum biomarkers with motor impairment in stroke patients
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •unilateral stroke patients
- •admission to the rehabilitation department before 1 month after stroke onset
- •mild to severe motor impairment at time of transferring to the rehabilitation department
排除标准
- •Progressive or unstable stroke
- •Pre-existing and active major neurological disease
- •Pre-existing and active major psychiatric disease
- •Advanced liver, kidney, cardiac, or pulmonary disease
- •A terminal medical diagnosis consistent with survival < 1 year)
- •Pregnant or lactating woman
结局指标
主要结局
Serum BDNF
时间窗: At 2 weeks after the comprehensive inpatient rehabilitation
serum BDNF level
次要结局
- MMP-9(At 2 weeks after the comprehensive inpatient rehabilitation)
- Serum proBDNF(At 2 weeks after the comprehensive inpatient rehabilitation)
研究者
Won Hyuk Chang
Associate Professor
Samsung Medical Center