Pediatric Kidney Transplant
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 4
- 主要终点
- Surgical outcomes
研究概览
简要总结
End-stage renal disease (ESRD) is a rare disease in children. Renal transplantation (RT) is the treatment of choice for ESRD in the pediatric population. In France, around 100 pediatric kidney transplants are performed each year. The aim was to evaluate the surgical management of TR and the long-term results.
详细描述
End-stage renal disease (ESRD) is a rare pathology in children, whose gold standard treatment is a kidney transplant. In France, around 100 pediatric kidney transplants are performed every year.
Although the first adult kidney transplants were performed in 1954, pediatric renal transplantation was considered unsafe compared with dialysis, which was preferred. In the 1980s, improved graft selection, optimized pre-transplant management and a better understanding of the immune system led to the development of pediatric kidney transplantation.
Despite considerable progress, graft survival in these long-lived patients remains a major challenge.
The aim of this study is to evaluate surgical practices in the four French pediatric transplant centers, and to define risk factors for surgical complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All pediatric patients who underwent renal transplantation in one of the 4 centers
排除标准
- •Multi organ transplant
结局指标
主要结局
Surgical outcomes
时间窗: 10 years
To assess surgical outcome in pediatric renal transplantation in terms of * per operative complications (ClassIntra classification) * post operative complications (Clavien Dindo) early \< 30 days and late \> 30 days
次要结局
- Retransplantation(10 years)
- Surgical complications(10 years)
- Return to dialysis(10 years)
- Death(10 years)
- Graft Survival(10 years)