Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients

Completed

• Conditions: Blood Platelets; Extracorporeal Membrane Oxygenation; Intensive Care Units; Platelet Activation; Platelet Aggregation; Platelet Function Tests

• Registration Number: NCT03355625
• Lead Sponsor: Aarhus University Hospital

Brief Summary

The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding of the mechanisms underlying their coagulopathy.

The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).

Detailed Description

The knowledge of platelet function during extracorporeal membrane oxygenation (ECMO) remains sparse. In the present study, the aim is to investigate platelet function in adult patients treated with ECMO using flow cytometry. The investigators hypothesize that platelet function increases from day 1 to day 3 in patients treated with ECMO. The secondary aim is to investigate the association between platelet function and the incidence of bleeding episodes and thrombosis during ECMO treatment.

The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).

Study Timeline

• Study Start: 2017-09-01
• Study First Submitted: 2017-11-22
• Study First Submitted QC: 2017-11-22
• Study First Posted: 2017-11-28
• Primary Completion: 2019-09-30
• Study Completion: 2019-11-30
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-25
• Last Update Posted: 2022-05-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• Treatment with veno-venous or veno-arterial ECMO
• Age ≥18 years

Exclusion Criteria

• ECMO treatment initiated post-operatively

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in platelet function	Platelet function measured day 1 and day 3 on ECMO	Platelet function on day 3 compared with day 1 on ECMO. Measured by flow cytometry

Secondary Outcome Measures

Name	Time	Method
Changes in platelet aggregation	Platelet function measured every morning from day 1 to day 8 on ECMO (except weekends).	Comparison of platelet aggregation measured by whole blood impedance aggregometry (Multiplate).
Immature platelet count	Measured every morning from day 1 to day 8 on ECMO (except weekends)	Estimation of platelet turn-over measured by a blood analyzer (Sysmex)
Platelet count	Measured every morning from day 1 to day 8 on ECMO (except weekends)	Estimation of platelet count measured by a blood analyzer (Sysmex)

Trial Locations

Locations (2)

Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark

Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark