Sex-Informed Data in the COVID-19 Pandemic.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Sex differences in platelet and immune function and COVID19 severity
研究概览
简要总结
Sex and gender matter to health equity, especially in a pandemic. Sex (a biological attribute) and gender (a social construct) may influence an individual's susceptibility, vulnerability and exposure to infectious disease. In previous coronavirus epidemics (SARS and MERS), male sex was associated with worse outcomes. Both immune and the hemostatic response display ample sexual dimorphism.
The primary aim of the study is to determine whether sex differences in biomarkers of platelet and immune function, gut microbiome, clinical characteristics, therapy, clinical cost sensitive outcomes (i.e. in-hospital transition of care, case severity, and mortality due to COVID-19) exist in patients affected by COVID-19.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with laboratory confirmed SARS-Cov-2 infection of any severity.
排除标准
- •Pregnancy.
- •Younger than 18 years of age.
结局指标
主要结局
Sex differences in platelet and immune function and COVID19 severity
时间窗: 3 months
Sex differences in biomarkers of platelet and immune function correlate with severity of disease
次要结局
- Gut microbiome and COVID19 severity(3 months)
研究者
Stefania Basili
Full Professor of Internal Medicine
University of Roma La Sapienza