Effects of an ARB on microcirculation in essential hypertensio

Phase 4

Completed

• Conditions: Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics); Disease: Cardiovascular; Circulatory System; Hypertension

• Registration Number: ISRCTN62554526
• Lead Sponsor: St George's, University of London (UK)

Brief Summary

1. 2017 results in http://openaccess.sgul.ac.uk/109036/ (added 24/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-05-12
• Study Completion: 2014-10-01
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

1. Male and female, aged 18 years or older
2. Uncomplicated mild-to-moderate essential hypertension, i.e., sitting diastolic blood pressure (BP) greater than or equal to 90 to less than 110 mmHg and/or systolic BP greater than or equal to 140 to less than 180 mmHg)
3. Not previously treated for their high blood pressure
4. Caucasian and light-coloured Asians only, this is due to the technical difficulty of performing capillaroscopy in dark-skinned individuals

Exclusion Criteria

1. Malignant or accelerated hypertension
2. Serum creatinine greater than 180 µmol/L
3. Ischaemic heart disease
4. Cerebrovascular disease
5. Impaired liver functions
6. Diabetes mellitus
7. Pregnancy or risk of pregnancy
8. Lactation
9. History of alcoholism, drug abuse or other problems that are likely to invalidate the informed consent
10. Dark-skinned individuals (capillary microscopy can't be performed)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The increase in maximal capillary density at the end of 8 weeks treatment.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Change in aortic augmentation index at 8 weeks<br> 2. Change in basal capillary density at 8 weeks<br> 3. Reduction in microalbuminuria at 8 weeks<br> 4. Improvement in pulse wave velocity at 8 weeks<br>