EEG Measurements to Capture DBS-induced Electric Potentials

Recruiting

• Conditions: Deep Brain Stimulation; Parkinson's Disease

• Registration Number: NCT07115394
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

To measure the electric fields induced by DBS (deep brain stimulation) on the scalp and to improve electric field simulations, the investigators will measure EEG (electroencephalography) measurements with high sampling rates (\>100 kHz). The investigators hypothesize that we can improve electric field simulations of DBS by validating and calibrating the simulations based on EEG measurements at high sampling rates (\>100 kHz).

Detailed Description

Not available

Study Timeline

• Study Start: 2025-07-11
• Status Verified: 2025-08
• Study First Submitted: 2025-08-03
• Study First Submitted QC: 2025-08-03
• Study First Posted: 2025-08-11
• Last Update Submitted: 2025-08-17
• Last Update Posted: 2025-08-21
• Primary Completion: 2026-08-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Provision of written informed consent by the patient
• Age 35 - 85
• patient groups: Parkinson's disease, essential tremor, dystonia
• >3 months after surgery for DBS

Exclusion Criteria

none.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Electric potential at the EEG locations	during DBS	The investigators will extract the DBS pulses from the EEG data and check the distribution of the electric potentials as seen in simulations based on individual MRI and CT images. Parameters of the simulation pipeline (e.g. conductances) will be adjusted so that the simulation models fit the data.

Trial Locations

Locations (1)

University Medical Center Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany