A COMPARITIVE CLINICAL STUDY TO EVALUATE THE EFFECT OF HINGWADI GHRITA AND MOORCHITA GHRITA PRATIMARSHYA NASYA FOR ADOLESCENTS IN THE MANAGEMENT OF GENERALIZED ANXIETY
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- There is significant effect of Hingwadi ghrita pratimarshya nasya over moorchita ghrita
研究概览
简要总结
Adolescent age is the emotionally unstable age where majority of the drastic changes happens
in life such as onset of puberty, choosing career, failures, developing a sense of identity etc.
Such stressful events contribute to the development of anxiety.
Anxiety disorders are the most common psychiatric disorders of childhood occurring in 5 –
18 % of children and adolescents. The prevalence of generalized anxiety disorder ranges from
2.5 – 6% of children.2
The research studies has shown that there is a significant burden of anxiety disorders among
adolescents in India. As this burden of anxiety disorder can cause significant morbidity and
depression in future in the population, effective intervention should be planned to address
this. Simultaneously, the burden of other mental disorders should also be estimated in
adolescents in India. With respect to major depression, a worldwide survey reported that
45.7% of individuals with lifetime major depressive disorder had a history of one or more
anxiety disorder3 and among them 43% were with generalized anxiety disorder.4
In modern medicine anxiolytics such as, benzodiazepines, 5HT reuptake inhibitors
antidepressants, beta-adrenergic blockers are used to manage anxiety disorder but it has
severe adverse effects such as cerebral ataxia, drug dependence, withdrawal symptoms,
arrhythmia, hypotension, sexual dysfunction, drug toxicity in body etc.5 In many ayurvedic
samhitas it has stated that Nasya and shirodhara are the two major panchakarma process in
all types of urdhwajatrugata vikara. Nasya is found to be more effective than shirodhara in
the management of generalized anxiety6
It is coated that “Nasa hi sirso dwaram” and pratimarshya nasya is ajanma satmya to
everyone.7
Unmada is a group of different psychological disorders including including anxiety8,9.
Symptoms of generalized anxiety can be correlated with vataja unmada.
In many ayurvedic samhitas Hingwadi ghrita has been mentioned uder the unmada chikitsa
adhyaya 10,11,12,13, it is dipana, pachana, medhya, indriyaprasadak, vatahara gunas with
stimulant properties and it helps to balance vitiated doshas. The drug as whole is medhya,
ojasya, rasayana. Contents of hingwadi ghrita is effective against various CNS disorders.14
Ghrita is one of the nitya rasayanas,15 along with it is smritivardhaka,medhya,deepaa,ojasya,
and unmadahara. After the moorchana samskara over ghrita its efficacy gets increased by
thousand times and called as moorchita ghrita.16
Hence, if we prevent generalized anxiety disorder by ayurvedic management by pratimarshya
nasya in adolescents, then we will be able to deliver the healthy society in future.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 12.00 Year(s) 至 18.00 Year(s)(—)
- 性别
- All
入选标准
- •Adolescent will be diagnosed for general anxiety aged between 12 to 18 years according to the DSM-5 Diagnostic Criteria for Generalized Anxiety Disorder irrespective of the gender religion caste and socioeconomical status.
排除标准
- •Adolescents who are unfit for nasyakarma Adolescents who are already diagnosed with depression and is on medication for the same.
- •Adolescents with other medical condition such as hyperthyroidism, diabetes or any severe systemic illness.
结局指标
主要结局
There is significant effect of Hingwadi ghrita pratimarshya nasya over moorchita ghrita
时间窗: 4 months
pratimarshya nasya in adolescents for the management of generalized anxiety.
时间窗: 4 months
次要结局
- There is no significant difference between the effect of Hingwadi ghrita pratimarshya(nasya and moorchita ghrita pratimarshya nasya in adolescent for the management of)
研究者
Vishal Kawade
Shree Jagadguru Gavisiddheswara Ayurvedic Medical College and hospital
