Effect of Blood Transfusion in Patients Undergoing Neurosurgery

Not Applicable

Completed

• Conditions: Health Condition 1: null- Patients undergoing elective intrancranial neurosurgery

• Registration Number: CTRI/2018/05/013887
• Lead Sponsor: All India Institute of Medical sciences AIIMS New Delhi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-11-01
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 130

Inclusion Criteria

a) Patients undergoing elective intracranial meningioma neurosurgery.

b)Received transfusion of more than 1 units of PRBCs during surgery

Exclusion Criteria

a) Patients <18yrs or >70yrs of age.

b) Having received blood transfusion in less than 6 months prior to the surgery.

c) Patient undergoing emergency neurosurgery.

d) Patient with any form of active infection; respiratory, UTI

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We expected that after transfusion of leukoreduced blood components there are less than 20 % changes in cytokines (INF-γ) level in their blood as compared to non-leukoreduced blood component transfusion.Timepoint: We expected that after transfusion of leukoreduced blood components there are less than 20 % changes in cytokines (INF-γ) level in their blood as compared to non-leukoreduced blood component transfusion.

Secondary Outcome Measures

Name	Time	Method
1.There are less incidence of postoperative infections and <br/ ><br>2.Reduces the length of stay of patients in ICU and hospitals and <br/ ><br>3.Reduces the mortality in patients undergoing neurosurgery.Timepoint: 7 days and 30 days