Liposomal Bupivacaine in Paravertebral Block for the Treatment of Pain After Video-assisted Thoracoscopic Lobectomy

Phase 4

Recruiting

• Conditions: Acute Pain; Chronic Pain; Postoperative Pain

• Registration Number: NCT06569953
• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-8-13
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Participants who scheduled for elective video-assisted thoracoscopic lobectomy under<br> general anesthesia.<br><br> - Participants were 18 years or older.<br><br> - 18 kg/m2=BMI=30 kg/m2<br><br> - Participants with American Society of Anesthesiology (ASA) physical status I-III.<br><br> - Understand the significance, possible benefits, potential risks of the trial in<br> detail.Understand the procedures and methods of this study.Willing to complete the<br> trial in strict compliance with the clinical trial protocol.Sign the informed<br> consent form voluntarily.<br><br>Exclusion Criteria:<br><br> - with severe cardiovascular and cerebrovascular diseases such as myocardial<br> infarction,unstable angina pectoris,severe cardiac rhythm disorders (second- and<br> third-degree heart block,etc.), New York Heart Association (NYHA) functional class<br> III/IV,Ischemic stroke.<br><br> - with psychiatric disorders (such as schizophrenia,depression,etc.) and cognitive<br> impairment.<br><br> - with sensory disorders such as hyperalgesia.<br><br> - with other bodily pain.<br><br> - allergy to amide-type local anesthetics or any of the trial drugs<br><br> - taking drugs that affect liver<br> metabolism,corticosteroids,benzodiazepines,non-steroidal anti-inflammatory<br> drugs(NSAIDs),opioid agonist-antagonist,central-alpha<br> 2-agonists,anticonvulsants,antidepressants within 72h.<br><br> - with a history of alcohol or opioid abuse.<br><br> - who were pregnant or lactating.<br><br> - who were currently included in another clinical study within 3 months.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Area under the movement-evoked pain intensity-time curve;The incidence of chronic postoperative pain

Secondary Outcome Measures

Name	Time	Method
Area under the rest pain intensity-time curve;Movement-evoked pain score;Pain score at rest;Proportion of participants who did not use rescue analgesia;The cumulative dosage of rescue analgesia;The time of first use of rescue analgesia;First time out-of-bed;Length of hospital stay;Chronic pain score;Score of satisfaction with analgesia