Myocardial Biopsy in Congenital Cardiac Surgery
- Conditions
- Myocardial Protection
- Registration Number
- NCT03595111
- Lead Sponsor
- Assiut University
- Brief Summary
Despite major advances in the technical aspects of surgical repair of congenital heart diseases, perioperative myocardial damage with low cardiac output remains the most common cause of morbidity and death after repair of congenital heart lesions.
- Detailed Description
Myocardial sample was obtained from the endocardial surface of the right ventricle and placed in formalin until examination under light microscopy for detection of myocyte cellular edema as a marker of ischemic changes.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Scheduled cardiac surgery requiring cardioplegic arrest with expected cross clamp time>45 minutes.
Hemodynamic stability.
Previous cardiac surgery. Urgent or emergent cases. Any known allergies to components of either cardioplegia solutions.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Myocardial biopsy within 24 hours Myocardial cell edema either focal or diffuse was detected in histopathological examination
- Secondary Outcome Measures
Name Time Method The inotropic score within one month 1 point is assigned for each mcg/kg/min of dopamine and dobutamine, and 10 points is assigned for each 0.1 mcg/kg/min of epinephrine, norepinephrine, and phenylephrine. (i.e. 1 point is assigned for each 10 ng/kg/min of epinephrine, norepinephrine, and phenylephrine.
Serum cardiac troponin level first 24 hours Samples for troponin I levels at baseline, 6, 12 and 24 hours after aortic cross-clamping.
30-day mortality 30 days number of patients died
Type of cardiac rhythm on return within 24 hours Type of cardiac rhythm on return