Does Intraoperative Myocardial Biopsy Have Any Prognostic Value in Predicting Myocardial Protection After Congenital Cardiac Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Myocardial biopsy
研究概览
简要总结
Despite major advances in the technical aspects of surgical repair of congenital heart diseases, perioperative myocardial damage with low cardiac output remains the most common cause of morbidity and death after repair of congenital heart lesions.
详细描述
Myocardial sample was obtained from the endocardial surface of the right ventricle and placed in formalin until examination under light microscopy for detection of myocyte cellular edema as a marker of ischemic changes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled cardiac surgery requiring cardioplegic arrest with expected cross clamp time>45 minutes.
- •Hemodynamic stability.
排除标准
- •Previous cardiac surgery. Urgent or emergent cases. Any known allergies to components of either cardioplegia solutions.
研究组 & 干预措施
Myocardial biopsy
The specimens were classified into three categories: normal, focal hydropic change and diffuse hydropic change.
干预措施: myocardial biopsy (Procedure)
结局指标
主要结局
Myocardial biopsy
时间窗: within 24 hours
Myocardial cell edema either focal or diffuse was detected in histopathological examination
次要结局
- The inotropic score(within one month)
- Serum cardiac troponin level(first 24 hours)
- 30-day mortality(30 days)
- Type of cardiac rhythm on return(within 24 hours)
研究者
Sayed Kaoud Abd-Elshafy
Associate Profossor of Anesthesiology
Assiut University