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临床试验/CTRI/2025/12/099513
CTRI/2025/12/099513尚未招募不适用

Assessment of volume responsiveness using internal jugular vein distensibility index(IJV DI) in mechanically ventilated patients with decompensated chronic liver disease(DCLD) and septic shock A prospective observational study

Institute of liver and biliary sciences1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2026年1月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
150
试验地点
1

研究概览

简要总结

Decompensated chronic liver disease refers to cirrhosis complications such as ascitis  jaundice hepatic encephalopathy variceal bleed They are often prone for septic shock because of the associated immune dysfunction bacterial translocation from gut poor nutrition etc Fluid management can be challenging because of underlying splanchnic vasodilation hypoalbuminemia causing effective low circulatory volume risk of hepatorenal syndrome Hence fluid management in these cases should always be guided by dynamic measures than static measures IJV DI is one such ultrasound based dynamic measure which is repeatable non invasive Since traditional measures like inferior venacava distensibility is unreliable in these patients due to increased intra abdominal pressure our study aims to evaluate the role and ability of IJV distensibility index in predicting the fluid responsiveness in this population

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 90.00 Year(s)(—)
性别
All

入选标准

  • Diagnosis of decompensated chronic liver disease Septic shock as per sepsis 3 definition On controlled mechanical ventilation IJV accessible for ultrasound evaluation.

排除标准

  • ARDS Cardiac arrhythmias Central vein thrombosis Pregnancy Poor echocardiographic windows.

研究者

申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Sonam Satija

Institute of liver and biliary sciences

研究点 (1)

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