Perfusion Imaging With Myocardial Contrast Echocardiography in HCM
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Myocardial perfusion (ml/min/g) in the hypertrophied segment on myocardial contrast echo
研究概览
简要总结
The objective of this study is to determine whether myocardial contrast echocardiography in patients with cardiomyopathy (HCM) can detect resting hypo-perfusion due to fibrosis or stress induced perfusion defects due to associated abnormalities in intramyocardial arteries and the microcirculation. A secondary aim will be to determine whether abnormalities in perfusion are associated with either severity of symptoms (chest pain and dyspnea), presence of arrhythmias, and regional function of the septum.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-80 years
- •Established diagnosis of HCM
排除标准
- •Known history of coronary or peripheral artery disease
- •History of myocardial infarction
- •Pregnant or lactating females
- •Hypersensitivity to any ultrasound contrast agent
- •Evidence right-to-left or bi-directional intracardiac shunt
- •Moderate or greater valve disease other than from HCM (systolic anterior motion of the mitral valve)
- •History of septal ablation or myectomy
- •Hemodynamic instability
- •Pacemaker dependent heart rhythm
研究组 & 干预措施
Patients with HCM
This is a prospective, non-blinded single center study. Subjects with known HCM with variant will be recruited. MCE at rest and during vasodilator stress will be performed. Full echocardiography including for diastolic function and regional strain imaging will also be performed. Patient history and questionnaires will be used for evaluation of symptoms and arrhythmias.
干预措施: Echo and myocardial contrast echocardiography perfusion imaging (Drug)
结局指标
主要结局
Myocardial perfusion (ml/min/g) in the hypertrophied segment on myocardial contrast echo
时间窗: One hour
Myocardial contrast echo will be used to measure myocardial perfusion in ml/min/g of tissue in the hypertrophied segment. The data will be analyzed both in terms of absolute value of ml/min/g and also as a ration to normal tissue.
Myocardial blood flow reserve in the hypertrophied segment on myocardial contrast echo
时间窗: One hour
Myocardial blood flow reserve on myocardial contrast echo (ratio of flow during hyperemia to rest) will be calculated for the hypertrophied segment and expressed as an absolute value and relative to normal segments.
次要结局
- Spatial distribution of blood flow on myocardial contrast echocardiography(One hour)
研究者
Jonathan R. Lindner, MD
Professor
Oregon Health and Science University