Genetic Modifiers of Cystic Fibrosis (CF) Liver Disease

Active, not recruiting

• Conditions: Cystic Fibrosis; Liver Disease

• Registration Number: NCT00804583
• Lead Sponsor: University of North Carolina, Chapel Hill

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12-8
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

Inclusion Criteria:<br><br> - Volunteers with CF, regardless of genotype and age, who have severe liver disease<br> with portal hypertension (big spleen, i.e. splenomegaly and/or presence of<br> enlarged vessels in the esophagus, i.e. esophageal varices) may be eligible to<br> participate. This would include any person who has been evaluated for a liver<br> transplant, or has already received a liver transplant.<br><br>Exclusion Criteria:<br><br> - History of Alcohol Abuse<br><br> - History of Biliary Atresia<br><br> - History of Clinically Significant Hepatitis Infection<br><br> - History of Hepatic Vein Thrombosis<br><br> - History of Liver Cancer<br><br> - History of Portal Vein Thrombosis<br><br> - History of Clinically Significant use of total parenteral nutrition (TPN)<br><br> - History of Wilson's Disease

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This is not an interventional study