A clinical trial to compare the effects of two anaesthetic drugs- desflurane and isoflurane in patients undergoing elective neurosurgery.
Not Applicable
Completed
- Registration Number
- CTRI/2010/091/000616
- Lead Sponsor
- Dr Aparanjit Paul
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
a)Elective neurosurgical patients with supratentorial intra-axial mass lesions
b)Age 18 -75 years
c)ASA grade I - III
d)Pre-operative GCS ? 15/15
Exclusion Criteria
a)Previous craniotomy
b)Hepatic or renal disease (elevated SGOT/SGPT/ALP/creatinine)
c)Alcohol or drug abuse
d)Hypothyroidism? any thyroid function test outside normal limits
e)BMI > 35
f)Midline shift > 5mm on CT/MRI
g)Female patients ? pregnant/breastfeeding
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method i.Time to obeying motor commands<br>ii.Time to extubation<br>iii.Time to eye opening<br>iv.Time to orientation<br>v.Time to recovery of motor deficits <br>Timepoint: i-iv. At end of surgery <br>v. withing 12 hours after surgery
- Secondary Outcome Measures
Name Time Method I. Brain Relaxation Score <br>II. Number Of Episodes Of : Hypotension(MAP < 20% Baseline), Hypertension(MAP>20% Baseline) And Bradycardia (Heart Rate <45bpm)<br>Timepoint: During the surgery