Afterload Dependence of Right Ventricular Myocardial Remodeling and Intrinsic Right Ventricular Myocardial Function in Heart Failure With Preserved Ejection Fraction
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Phosphorylation of structural myocardial proteins
研究概览
简要总结
In patients with heart failure and preserved ejection fraction (HFpEF) right ventricular (RV) systolic and diastolic dysfunction are prognostically and functionally relevant factors but have mechanistically been neglected so far. In the present study alterations of intrinsic RV (systolic and diastolic) function, as assessed by invasive pressure volume loops, are examined in relation to tissue alterations on myocardial level and to the degree of RV afterload (pulmonary hypertension). Study aim is to gain insights into mechanisms contributing to the development of RV dysfunction and potentially identify new therapeutic targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical signs of heart failure
- •Preserved Left ventricular (LV) Ejection Fraction (EF >= 50%)
- •Structural Heart Diseases on echocardiogram/ N terminal-pro-brain natriuretic peptide > 125ng/l
- •Elevated LV end-diastolic pressure at rest (>15mmHg) or during exertion (>=25mmHg)
- •No Heart Failure
- •Inclusion Criteria:
- •No signs of heart failure
- •Preserved Left ventricular (LV) Ejection Fraction (EF >= 50%)
- •Normal LV end-diastolic pressure at rest (=<15mmHg) and during exertion (<25mmHg)
排除标准
- •Significant coronary artery stenosis at time of catheterization
- •Acute coronary syndrome or cerebral insult within 1 month of examination
- •more than moderate valvular diseases
- •pregnancy
- •contraindication to cardiac magnetic resonance imaging
结局指标
主要结局
Phosphorylation of structural myocardial proteins
时间窗: Baseline
Assessed on myocardial biopsy specimen
Right ventricular systolic and diastolic function
时间窗: Baseline
Assessed with pressure volume loops analysis
Biventricular myocardial fibrosis
时间窗: Baseline
Assessed with histopathology
次要结局
- Functional capacity(Baseline)
- Myocardial fibrosis on cardiac magnetic resonance(Baseline)