The effect of combined oral contraceptive pills on autophagy in ovarian endometrioma

Completed

• Conditions: Endometriotic cyst; Endometriosis; Combine oral pills; Endometrioma; Autophagy

• Registration Number: TCTR20170720002
• Lead Sponsor: Faculty of Medicine, Ramathibodi Hospital

Brief Summary

The baseline demographic data were not different among three groups. The Beclin-1 gene expression in endometrium tissue in COC group was significantly less than those in no treatment and control group.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-20
• Study Completion: 2018-05-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 36

Inclusion Criteria

1.No pregnant with intact uterus women age 20-40 years with endometriotic cyst needed laparoscopic surgery
2.Has suspected ovarian endometrioma diagnosed by ultrasonography size at least 3 cm
3.Regular menstrual cycle for more than 3 consecutive months
4.No oral hormonal treatment for at least 3 months, depot-medroxyprogesterone acetate (DMPA) or GnRH agonist for at least 6 before surgery
5.No NSAIDS treatment for at least 3 months before surgery
6.Willing to participate

Exclusion Criteria

1.Women with underlying diseases such as DM, HT, thrombosis, abnormal coagulation, heart disease, liver and gall bladder disease, cerebral arterial/venous diseases, cancer.
2.Contraindication for oral combine pills such as allergy to pill, abnormal vaginal bleeding, endometrial hyperplasia
3.Abnormal pap smear
4.Drink alcohol or smoking
5.Pathology result not endometriosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CIII, Beclin-1, Atg gene and protein expression 1 year RT-PCR, western blot and immunohistochemistry

Secondary Outcome Measures

Name	Time	Method
/A N/A N/A