Watermelon and Beetroot Products on Endothelial Function

Not Applicable

Completed

• Conditions: Older People With Cardiovascular Disease Risk; Healthy Young
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Watermelon; Dietary Supplement: Watermelon + beetroot; Dietary Supplement: Beetroot

• Registration Number: NCT04781595
• Lead Sponsor: Universidade Federal do Rio de Janeiro

Brief Summary

Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases. Endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. Due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as L-citrulline and nitrate on endothelial function parameters. The present study will evaluate the effect of L-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. Furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-02-23
• Study Start: 2021-03-01
• Study First Submitted QC: 2021-03-01
• Study First Posted: 2021-03-04
• Primary Completion: 2022-06-30
• Study Completion: 2022-07-31
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-21
• Last Update Posted: 2022-12-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Not provided

Exclusion Criteria

• Elevated fasting glucose (≥100 mg/dL);
• Smoking;
• Beetroot or watermelon allergy;
• Unwillingness to avoid beetroot or watermelon products during the entire study;
• Other chronic diseases (diabetes, liver disease, etc.) or acutely ill

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Maltodextrin
Watermelon	Watermelon	Watermelon powder containing 3 g of L-citrulline.
Watermelon + beetroot	Watermelon + beetroot	Watermelon powder containing 3 g of L-citrulline and Beetroot powder containing 8 mmol of nitrate.
Beetroot	Beetroot	Beetroot powder containing 8 mmol of nitrate.

Primary Outcome Measures

Name	Time	Method
Flow-mediated dilation (FMD)	This measure will be evaluate 120 minutes after the nutritional intervention
Muscle oxygen saturation	This measure will be evaluate 120 minutes after the nutritional intervention

Secondary Outcome Measures

Name	Time	Method
Plasmatic amino acids	This measure will be evaluate 120 minutes after the nutritional intervention
Plasmatic insulin	This measure will be evaluate 120 min after the nutritional intervention
Plasmatic glucose	This measure will be evaluate 120 min after the nutritional intervention

Trial Locations

Locations (1)

Universidade Federal do Rio de Janeiro; 🇧🇷 Macaé, Rio De Janeiro, Brazil