Effect of vitamin D supplementation and resistance training on muscle, bone, and inflammatory parameters in maintenance hemodialysis patients

Not Applicable

• Conditions: E02.870.300; Renal dialysis; Chronic kidney failure; sarcopenia; C12.777.419.780.750.500; C10.597.613.612.500

• Registration Number: RBR-3j787t
• Lead Sponsor: Associação Prudentina de Educação e Cultura APEC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-08-07
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Individuals older than 18 years; with chronic kidney disease on hemodialysis for a period greater than or equal to three months in the Hospital of Presidente Prudente Doutor Domingos Leonardo Cerávolo”, Presidente Prudente, São Paulo, Brazil; do not have contraindications to physical activity; and accept and sign the Informed Consent.

Exclusion Criteria

Individuals unable to understand the procedures performed; prior diagnosis of coronary artery disease; positive exercise test for cardiac ischemia; Patients who have suffered stroke; patients with cancer, liver failure, chronic infection or acute in activity; uncontrolled hypertension (> 160 mmHg systolic or > 100 mmHg diastolic); with amputated limbs; those that received cholecalciferol supplementation in the last 6 months; use of medications that affect body composition, such as corticosteroids and antiretroviral therapy.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Significant increase in muscle strength and functional capacity in the assessments before and after intervention period assessed by dynamometry and functional capacity tests, respectively. (There is no referential percentage, only the statistically significant increase is the expected outcome);Significant improve in inflammatory parameters (cytokines assessed by ELISA and immune system cells labeling by flow cytometry). <br>(There is no referential percentage, only the statistically significant increase is the expected outcome).

Secondary Outcome Measures

Name	Time	Method
Significant increase in soluble Klotho serum concentration assessed by ELISA.<br>(There is no referential percentage, only the statistically significant increase is the expected outcome).