Comparison of Telmisartan a blood pressure lowering agent with other blood pressure lowering agents on its effects on insulin sensitivity, inflammation and vascular function in patients of type 2 diabetes with high blood pressure : an open label interventional study
Phase 3
- Conditions
- Health Condition 1: I10- Essential (primary) hypertensionHealth Condition 2: E119- Type 2 diabetes mellitus without complications
- Registration Number
- CTRI/2023/04/051878
- Lead Sponsor
- ALL INDIA INSTITUTE OF MEDICAL SCIENCES Jodhpur Rajasthan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
18-75 years of age SBP >140 mmHg DBP >90mmHg Diagnosed case of T2DM HbA1c between 7% and 10% Patients on metformin and /or DPP4 inhibitors
Exclusion Criteria
Pregnancy lactation T1DM Patients with heart failure ischemic stroke hemorrhagic stroke Traumatic brain injury malignancy patients on steroids immunosuppressants over a long time patients on exogenous insulin patients on mental and immune system disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effect of telmisartan with other anti hypertensives on insulin resistance in terms of HOMA IR valuesTimepoint: Baseline and after three months
- Secondary Outcome Measures
Name Time Method compare the effect of telmisartan with other anti-hypertensives on the levels of inflammatory marker CRPTimepoint: Baseline and after 3 months;To compare the effect of telmisartan with other anti-hypertensives on the levels of inflammatory markers IL 6Timepoint: Baseline and after 3 months;To compare the effect of telmisartan with other anti-hypertensives on the levels of inflammatory markers TNF alphaTimepoint: Baseline and after 3 months;To compare the effect of telmisartan with other anti-hypertensives on the levels of vascular endothelin 1Timepoint: Baseline and after 3 months