Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With CRPS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Decrease of the pressure pain thresholds of the distal hand joints
研究概览
简要总结
The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the upper limb and a non-CRPS-group. The investigators assume that there will be a significant correlation between the investigated values in the CRPS-group whereas the non-CRPS-group shows no significant correlation.
详细描述
Pressure pain of the distal hand joints is a predominant symptom of CRPS. But so far, the diagnostic value of pressure pain in the diagnosis of CRPS has not been investigated. We compared the pressure pain thresholds of the carpus, metacarpophalangeal and proximal interphalangeal joints to a region of interest-based (ROI) analysis of a TBPS in patients with CRPS and patients with limb pain of other origin (non-CRPS-group).Additionally, the PPTs were established for a healthy control group to get reference data.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •every participant:
- •aged > 18 years with written informed consent
- •adequate understanding of the german language
- •indication for a TPBS independent of the study
- •Patients with CRPS:
- •patients with CRPS type 1 of the upper limb diagnosed on the basis of the budapest criteria (Harden, Bruehl et al., 2010)
- •unilateral pain
- •Control group:
- •patients with pain of the upper limbs of other origin than CRPS who underwent a TPBS
- •unilateral pain
- •Healthy subjects:
- •checked by the DFNS IMI questionnaire
排除标准
- •missing informed consent
- •inadequate understanding of the german language
- •disease duration of more than 12 months
- •other disease of the upper extremity (e.g. polyarthrosis, rheumatoid arthritis)
- •pregnancy/ lactation period
结局指标
主要结局
Decrease of the pressure pain thresholds of the distal hand joints
时间窗: half an hour
The pressure pain thresholds (PPT) were mesured for the carpus, metacarpophalangeal and proximal interphalangeal joints of both hands. The mean of three determined measurements of each joint was taken as the final value. Subseqently the PPT were compared to the results of the 3 phase bone scintigraphy and the reference data of the healthy subjects.
次要结局
- Increased bone metabolism in the 3 phase bone scintigraphy(3 hours)
研究者
Christoph Maier
Prof. Dr. med. (Head of the pain clinic of the Bergmannsheil University Hospital)
Ruhr University of Bochum