Malglycemia in the Pediatric Hematopoietic Stem Cell Transplant Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 344
- 试验地点
- 1
- 主要终点
- Number of patients with versus without malglycemia who experience infection
研究概览
简要总结
This is a retrospective chart review of patients who underwent a hematopoietic stem cell transplant (HSCT) between 1994 and 2016 to evaluate incidence of malglycemia and the relationship to specific outcomes.
详细描述
This is a retrospective chart review of patients who underwent a hematopoietic stem cell transplant between 2007 and 2016 to evaluate incidence and risk factors of malglycemia. The review will also aim to characterize relationships between specific outcomes and malglycemia in pediatric HSCT patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 0 to 30 years old at time of transplant
- •Bone Marrow Transplant (BMT) recipient at Children's Hospital Colorado (CHCO) between 1/1/2007 and 7/31/2016
排除标准
- •Preexisting diabetes mellitus or known hyperglycemia
- •Inadequate blood glucose data for analysis
结局指标
主要结局
Number of patients with versus without malglycemia who experience infection
时间窗: Transplant Day 0 to +100
It is hypothesized that patients who experience malglycemia will have an increased rate of post-transplant infections. This outcome will be assessed for differences in incidence based on malglycemia occurence
Number of patients experiencing malglycemia in primary admission for pediatric HSCT patients
时间窗: Transplant Day -14 to +100
hypoglycemia (BG \< 70 mg/dL), hyperglycemia (BG ≥ 126 mg/dL), or glycemic variability (σ ≥ 29 mg/dL)
次要结局
- Determine whether specific exposures are associated with increased occurrence of malglycemia(Transplant Day -14 to +100)
- Survival rate of patients with versus without malglycemia(Transplant Day 0 through date of relapse or death)
- Occurrence of graft-versus-host disease (GVHD) in patients with versus without malglycemia(Transplant Day 0 through date of relapse or death)