The Effects of Nanomicelles Curcumin on Glycemic Control, Serum Lipid Profile ,Blood Pressure and Anthropometric Measurements in Patients With Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- serum total Cholesterol
研究概览
简要总结
Metabolic syndrome is a condition which is recognized by abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. Curcumin has beneficial effects such as antioxidant and anti-inflammatory effects. nanomcielle curcumin will be used in this study because of the low bioavailability , fast metabolism and low absorption of curcumin powder. Therefore, this study is planned to determine the effects of supplementation of nanomicelle curcumin on glycemic control, serum lipid profile ,blood pressure and anthropometric measurements in patients with metabolic syndrome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •* waist circumference \>102 cm in men or \>88 cm in women
- •* Fasting blood glucose \>100 mg/dL
- •* Triglycerides (TG) \> 150 mg/dL
- •* High density lipoprotein cholesterol (HDL-C) \<50 in women or \<40 in men
- •* Systolic blood pressure (SBP) \>130 mmHg and diastolic blood pressure (DBP) \>85mmHg
排除标准
- •insulin administration for diabetes control
- •hypo- or hyperthyroidism,
- •renal failure or other chronic diseases
- •pregnancy and breastfeeding
- •taking weight loss supplements and obeying unusual weight loss plans
研究组 & 干预措施
nanomicielle curcumin
干预措施: nanomicielle curcumin (Dietary Supplement)
plecebo
干预措施: placebo (Dietary Supplement)
结局指标
主要结局
serum total Cholesterol
时间窗: 12 weeks
hemoglobin A1c (HbA1c)
时间窗: 12 weeks
serum glucose
时间窗: 12weeks
serum insulin
时间窗: 12weeks
homeostatic model assessment of insulin resistance(HOMA-IR)
时间窗: 12weeks
homeostatic model assessment of beta cell(HOMA-B)
时间窗: 12weeks
serum triglyceride (TG)
时间窗: 12 weeks
serum LDL-C
时间窗: 12 weeks
serum HDL-C
时间窗: 12 weeks
systolic blood pressure
时间窗: 12 weeks
diastolic blood pressure
时间窗: 12 weeks
serum curcumin
时间窗: 12 weeks
次要结局
未报告次要终点
研究者
Dr Azita Hekmatdoost
clinical professor
National Nutrition and Food Technology Institute