Comparison of intravenous administration (giving drug into the vein) of dexmedetomidine (sedative) versus dexamethasone (anti-inflammatory) for prevention of postanaesthetic shivering in patients undergoing laparoscopic cholecystectomy (surgical removal of gallbladder) under general anaesthesia
Phase 4
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/01/030598
- Lead Sponsor
- CMS and GTB Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of either gender giving consent for the study and aged
18-60 years belonging to ASA grade I or II scheduled for elective
laparoscopic cholecystectomy under general anaesthesia
Exclusion Criteria
1. Patients with history of myocardial infarction and insufficiency, neuromuscular disorders,
hypo- or hyperthyroidism, diabetes or convulsions
2. Pregnant females
3. Patients having pre-operative oral temperature >38â?° or <36â?° C
4. Patients with hemodynamic instability
5. Patients on anti-depressant medication, corticosteroid therapy or allergies to the study
drugs
6. Patients with heart blocks or arrhythmia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the incidence of PAS after intravenous administration of dexmedetomidine <br/ ><br>versus dexamethasoneTimepoint: 5 mins after administration of the drug, 10mins, 15mins, 30mins, 1h, 2h, 3h, At extubation, 15mins after extubation, 30mins, 1h, 2h, 3h, 4h
- Secondary Outcome Measures
Name Time Method Any other side effects <br/ ><br>Timepoint: 24h after extubation;Compare the severity of PAS after administration of either of the drugsTimepoint: 5 mins after administration of the drug, 10mins, 15mins, 30mins, 1h, 2h, 3h, At extubation, 15mins after extubation, 30mins, 1h, 2h, 3h, 4h;Hemodynamic parameters at the time of extubationTimepoint: At extubation;Incidence of PONV in each group <br/ ><br>Timepoint: At extubation, 15mins after extubation, 30mins, 1h, 2h, 3h, 4h;Postoperative hemodynamic parameters in both groupsTimepoint: 15mins after extubation, 30mins, 1h, 2h, 3h, 4h;Postoperative pain in both groupsTimepoint: At extubation, 15mins after extubation, 30mins, 1h, 2h, 3h, 4h;Postoperative sedation in both groupsTimepoint: At extubation, 15mins after extubation, 30mins, 1h, 2h, 3h, 4h;Severity grading of PONV in each groupTimepoint: At extubation, 15mins after extubation, 30mins, 1h, 2h, 3h, 4h