Sequential Treatment of Hepatocellular Carcinoma by Transarterial Chemoembolization and Local Ablation or External Radiation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- Lesion Response
研究概览
简要总结
Hepatocellular carcinoma (HCC) can present itself in many forms (size, number of lesions) for the treatment of which a therapeutic panel can be elaborated and layered. If a curative treatment cannot be considered in case of an HCC classified in an intermediate stage, a Transcatheter Arterial Chemoembolization (TACE) can be proposed. In case of a partial response or the treatment of some lesions of a multifocal HCC, a combined treatment by stereotaxic radiotherapy (CK), radiofrequency ablation (RFA) or microwave ablation (MWA) may be initiated in accordance with a decision of the multidisciplinary consultation meeting.
The aim of this study was to evaluate the clinical outcome of HCC receiving MWA, RFA or CK after downstaging with TACE.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a HCC treated by TACE followed by RFA, MWA and/or CK
- •from 01/2010 to 12/2020
- •treated by Nancy Regional University Hospital (TACE, RFA, MWA) and Institut de Cancérologie de Lorraine (CK)
排除标准
- •Combined treatment over one year following the last TACE
- •No baseline, in between or after combined treatment imaging
- •Lesion appeared after TACE treatment
结局指标
主要结局
Lesion Response
时间窗: 4-6 weeks after BWA or RFA or 3-6 months after CK
Lesion response after combined treatment
次要结局
- Delayed Lesion Response(1 year after BWA, RFA or CK)
研究者
Valérie LAURENT
MD, PhD
Central Hospital, Nancy, France