Use of Coconut Nourish and Queen Garnet Plum to Improve Health in an Elderly Population
- Conditions
- Healthy Ageing
- Registration Number
- NCT03594097
- Lead Sponsor
- University of Manitoba
- Brief Summary
The purpose of this study is to identify whether the combination of coconut Nourish and Queen Garnet plum are able to attenuate ageing-related complications, including muscle mass loss and inflammation. The study endpoints will measure muscle mass as the primary endpoint with blood lipids, glucose, blood pressure, and inflammatory markers serving as some of the secondary endpoints. As the two products are rich in dietary fibre and anthocyanins, respectively, the study outcome will help to understand role of these dietary components in improving complications that are seen quite frequently in elderly population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 7
- Aged 65 years and above
- Able to give written informed consent
- Able to read, write and speak English
- Body mass index less than or equal to 30 kg/m^2
- Either do not suffer from a chronic disease or, if suffering from a chronic disease, then key parameters (blood pressure, blood lipids concentration and blood glucose concentrations) are within the normal physiological range
- Either take no chronic medication or have been treated with a stable dosage of medication for at least 3 months as confirmed by family physician.
- Either take no supplements, or have been utilizing supplements in a stable and consistent dose for at least 3 months, and plan to continue taking a stable and consistent dose throughout the entire study.
- Smokers
- Consumption of more than 2 alcoholic drinks/day, or > 14 alcoholic beverages a week, or history of alcoholism or drug dependence
- Uncontrolled hypertension, recent stroke or myocardial infarction, hypothyroidism, diabetes mellitus or kidney disease
- Major disability or disorder requiring continuous medical attention and treatment such as chronic heart failure, liver disease, renal failure or cancer, chronic infections or major surgery within 6 months prior to randomization
- Despite taking medication, do not have values for key parameters (blood pressure, blood lipids concentration and blood glucose concentrations) within normal physiological ranges
- Fasting glucose ≥ 5.6 mmol/L
- Triglycerides ≥ 1.7 mmol/L
- Systolic and diastolic blood pressures ≥130/85 mmHg
- High-density lipoprotein cholesterol ≤1.0 mmol/L
- Have gained or lost >10 lbs in the previous 3 months, or plan to lose weight at any time during the study
- History of allergy to coconut, plum, plain flour, butter or milk
- Any planned surgeries during the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Lean mass 8 weeks Measured using dual-energy x-ray absorptiometry (DXA)
- Secondary Outcome Measures
Name Time Method Blood triglycerides 8 weeks Body mass index 8 weeks Weight and height will be combined to report BMI in kg/m\^2
Blood interleukin 1 beta 8 weeks Blood low-density lipoprotein cholesterol 8 weeks Triceps skinfold 8 weeks Calf circumference 8 weeks Arm circumference 8 weeks Bone mineral density 8 weeks Measured using DXA
Bone mineral content 8 weeks Measured using DXA
Blood glucose 8 weeks Body weight 8 weeks Waist circumference 8 weeks Handgrip dynamometer 8 weeks Blood C-reactive protein 8 weeks Wrist circumference 8 weeks Blood total cholesterol 8 weeks Five times chair standing test 8 weeks Blood pressure 8 weeks Systolic and diastolic pressure will be assessed
Heart rate 8 weeks Fat mass 8 weeks Measured using DXA
Blood high-density lipoprotein cholesterol 8 weeks Blood tumor necrosis factor alpha 8 weeks
Trial Locations
- Locations (2)
University of Southern Queensland
🇦🇺Toowoomba, Queensland, Australia
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba
🇨🇦Winnipeg, Manitoba, Canada
University of Southern Queensland🇦🇺Toowoomba, Queensland, Australia