Sirolimus improves renal function among liver/kidney transplant with abnormal creatinine level: a real world study

Phase 4

Recruiting

• Conditions: Liver transplantation, kidney transplantation

• Registration Number: ChiCTR2400088828
• Lead Sponsor: Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1.Aged 18-75 adult male and female<br>2. First time to receive liver transplantation or kidney transplantation<br>3. For kidney transplantation, Creatinine > 133mmol/L<br>4. For liver transplantation, Creatinine > upper limit of normal <br>5. No history of sirolimus<br>6. Signed informed consent

Exclusion Criteria

1. multiple organ transplantation<br>2. Patients with previous allergies to sirolimus and its derivatives<br>3. (TG)>300 mg/dL;(TC)>350 mg/dL<br>4. Severe local or systemic infection<br>5. Known HIV infection<br>6. Platelet < 75000/ml<br>7. Women with family plan<br>8. No use of drug that could affect the test result of creatinine, such as calcium dobesilate capsules and phenethylamine<br>9. proteinuria>0.8g/day

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Creatinine;

Secondary Outcome Measures

Name	Time	Method
acute rejection;BK polyomavirus infection rate;Incidence of BK polyomavirusassociated nephropathy;blood pressure control;fasting blood-glucose;lipid management;management of albuminuria;