Hysterectomy for Benign Gynaecological Conditions With or Without Tubectomy

RATIONALE Recent studies in women at hereditary high risk to develop ovarian cancer indicate that high grade serous carcinomas arise from (ectopic and/or dysplastic) tubal epithelium. Historically, in pre-menopausal women undergoing a hysterectomy for benign indications (such as bleeding disorders, fibroids and adenomyosis) adnexa, including the Fallopian tubes, are left in situ. However, removing the tubes during a hysterectomy potentially prevents the development of serous ovarian carcinomas. Such a simple preventive procedure should avoid serious adverse effects of adnexectomy, like premature ovarian failure (POF).

STUDY DESIGN This is a randomized controlled trial in which patients undergoing a hysterectomy for benign indications will either be included into a group in which a standard hysterectomy (abdominal or laparoscopic) will be performed or into a group in which hysterectomy (abdominal or laparoscopic) will be combined with salpingectomy.The accrual is aimed to take until July 2015 and will be performed in the regular clinical setting.

STUDY POPULATION Women undergoing hysterectomy for benign conditions (fibroids, endosalpingiosis, bleeding disorders, etc) either abdominal or laparoscopic.

SAMPLE SIZE N=50/arm

TREATMENT Hysterectomy (abdominal or laparoscopic) with or without bilateral tubectomy.