Investigation of the Use of 1 Minute Sit to Stand Test to Evaluate Physical Capacity and Effort-Related Desaturation in Individuals With Amyotrophic Lateral Sclerosis

Dyspnea ALS 15 (DALS-15)

时间窗: Time Frame: Baseline

The DALS-15 is a one-dimensional scale developed to assess shortness of breath in ALS patients. It can be applied very quickly and easily. The questionnaire consists of 15 questions that the patient can easily answer on their own. The patient expresses his/her condition in the last 2 weeks using a 3-point Likert scale (0=never, 1=occasionally, and 2=often). The total score ranges from 0 (no dyspnea) to a maximum of 30 (severe dyspnea). The higher the score, the greater the severity of dyspnea. In this study, the shortness of breath status of the participants will be evaluated with this scale.

Modified Borg Scale (MBS)

时间窗: Time Frame: Baseline

It will be used to evaluate dyspnea and lower extremity muscle fatigue of individuals with ALS before and after the 6 minute walking test and 1 minute sit to stand test. MBS is a scale that is frequently used to evaluate the severity of dyspnea on exertion and severity of dyspnea at rest. It consists of ten items describing the severity of dyspnea according to their degrees.It is similarly used to determine lower extremity fatigue; zero indicates no fatigue in the lower extremities, while the person experiencing maximal fatigue gets 10 points.

Quadriceps Muscle Strength

时间窗: Time Frame: Baseline

Quadriceps muscle strength will be evaluated bilaterally using a hand held dynamometer. Measurements were to be repeated 2 times in the manual muscle test position and with adequate rest intervals, with the highest value recorded in pounds (lbs). In this study, the quadriceps muscle strength of the participants will be evaluated with this test.

Oxygen Saturation Measurement (SpO2 Measurement)

时间窗: Time Frame: Baseline

Before and after the 6 minute walking test and 1 minute sit to stand test, the SpO2 of the participants will be evaluated with by pulse oximetry. A pulse oximeter is a small, light weight device used to monitor the amount of oxygen carried in the body and also heart rate. This non invasive tool will be attached painlessly to paticipants fingertip, sending two wave lengths of light through the finger to measure paticipants heart rate and how much oxygen is in the system. An oxygen saturation level of 95 percent is considered typical for most healthy people. Lower than this percent can indicate low level of oxygen in the blood.

ALS Functional Rating Scale (ALSFRS)

时间窗: Time Frame: Baseline

ALSFRS, which is used to evaluate the functional status of individuals with ALS, is a scale consisting of 12 parameters: speech, salivation, swallowing, handwriting, feeding, dressing and self-care, turning and covering in bed, walking, climbing stairs, dyspnea, orthopnea and respiratory failure. And evaluated out of a total of 48 points. Each question is scored between 0 and 4 points. While the functionally normal patient gets four points, the scores decrease from four depending on the functional deterioration and zero point is given to the worst functional condition. In this study, the functional levels of the participants will be evaluated with this scale.

1 Minute Sit to Stand Test (1MSTS)

时间窗: Time Frame: Baseline

1MSTS will be administered using an armless chair (height = 43 cm). Participants will be asked to sit and stand as quickly and safely as possible for one minute from the time the time starts. The number of times to get out of the chair completed in one minute will be counted and recorded as the test result. In this study, the functionality of the participants will be evaluated with this test.

6 Minutes Walking Test (6MWT)

时间窗: Time Frame: Baseline

The 6MWT is a submaximal exercise test used to evaluate aerobic capacity and endurance. The distance traveled during the test is used as an outcome measure to determine physical capacity. In this context, an area of 30 meters long will be determined with cones, and the participants will be asked to walk the maximum distance they can walk between two cones for six minutes. At the end of each minute, a standardized notification will be given, reminding the remaining time and instructing to continue. After six minutes, the total distance walked will be recorded in meters. The greater the distance walked, the greater the test result. In this study, the physical capacity of the participants will be evaluated with this test.

Heart Rate Measurement

时间窗: Time Frame: Baseline

Before and after the 6 minute walking test and 1 minute sit to stand test, heart rate of the participants will be evaluated with by pulse oximetry. A pulse oximeter is a small, lightweight device used to monitor the amount of oxygen carried in the body and also heart rate. Heart rate, is the number of times the heart beats per minute. A normal resting heart rate should be between 60 to 100 beats per minute. Lower than 60 and higher than 100 can indicate heart rate anomaly.