Delirium, Electroencephalographic Alterations and Cortical Spreading Depression in Critical Illness
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Delirium
- Sponsor
- Glostrup University Hospital, Copenhagen
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- The occurence of electroencephalographic alterations and potential electroencephalographic signatures prior to and during delirium in the ICU
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Delirium in the intensive care unit is an acutely developed brain dysfunction affecting up to 80 % of patients. It is associated with significantly increased morbidity and mortality during admission and post-discharge. The mechanism behind the condition is poorly understood but assumably multifactorial, and the purpose of this study is to investigate the pathophysiology further.
Detailed Description
The pathophysiology behind delirium in critical illness is not clarified but assumed to involve inflammation, changes in cerebral perfusion and neurotransmission, sleep deprivation and the use of i.e. sedatives. Cortical spreading depression is a phenomenon occuring in critically ill patients with acute cerebral trauma and likely associated with significant secondary neuron damage. The hypothesis is that 1. Delirium in critically ill patients without acute cerebral damage is a clinical manifestation of cortical spreading depression and can be recorded in a noninvasive direct current-electroencephalography 2. Electroencephalographic alterations or potentially specific signatures occur in delirium and thus, delirium can be predicted by recording continuous alternate current electroencephalography on admission in an ICU
Investigators
Rikke Malte Nielsen, M.D.
M.D.
Glostrup University Hospital, Copenhagen
Eligibility Criteria
Inclusion Criteria
- •expected admission in the ICU \>24 hours
Exclusion Criteria
- •Cerebral trauma \<6 months
- •existing delirium
- •severe dementia
Outcomes
Primary Outcomes
The occurence of electroencephalographic alterations and potential electroencephalographic signatures prior to and during delirium in the ICU
Time Frame: 7 days
Secondary Outcomes
- The occurence of cortical spreading depression in noninvasive direct current-EEG in critically ill patients without acute cerebral trauma(Cortical spreading depression in the ICU)