Combination Chemotherapy and Peripheral Stem Cell Transplant in Treating Patients With Relapsed Hodgkin's Lymphoma
- Conditions
- Registration Number
- NCT00025636
- Lead Sponsor
- German Hodgkin's Lymphoma Study Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplant may allow the doctors to give higher doses of chemotherapy drugs and kill more cancer cells. It is not yet known which combination chemotherapy regimen given before peripheral stem cell transplant is more ef...
- Detailed Description
OBJECTIVES:
* Compare the efficacy of induction chemotherapy followed by combination chemotherapy and autologous peripheral blood stem cell transplantation with or without high-dose sequential chemotherapy in terms of freedom from treatment failure in patients with relapsed Hodgkin's lymphoma.
* Compare the toxicity of these regimens in these patients.
...
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 220
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficacy at 3 months Toxicity at 3 months
- Secondary Outcome Measures
Name Time Method Complete remission at 3 months Overall survival at 3 months Relapse-free survival at 3 months
Trial Locations
- Locations (44)
Ziekenhuis Netwerk Antwerpen Middelheim
π§πͺAntwerp, Belgium
Universitaetsklinikum Essen
π©πͺEssen, Germany
Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet
π©πͺGreifswald, Germany
Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin
π©πͺBerlin, Germany
University Hospital Rebro
ππ·Zagreb, Croatia
Academisch Ziekenhuis Maastricht
π³π±Maastricht, Netherlands
Medizinische Universitaetsklinik I at the University of Cologne
π©πͺCologne, Germany
Universitair Ziekenhuis Antwerpen
π§πͺEdegem, Belgium
University Medical Center Groningen
π³π±Groningen, Netherlands
Evangelisches Krankenhaus Essen Werden
π©πͺEssen, Germany
Martin Luther Universitaet
π©πͺHalle, Germany
Universitaetsklinikum des Saarlandes
π©πͺHomburg, Germany
Charite - Campus Charite Mitte
π©πͺBerlin, Germany
Charite - Campus Virchow Klinikum
π©πͺBerlin, Germany
Medizinische Poliklinik
π©πͺBonn, Germany
Staedtisches Klinikum Dessau
π©πͺDessau, Germany
Klinikum der Universitaet Muenchen - Grosshadern Campus
π©πͺMunich, Germany
Academisch Medisch Centrum at University of Amsterdam
π³π±Amsterdam, Netherlands
Dr. Horst-Schmidt-Kliniken
π©πͺWiesbaden, Germany
Asklepios Klinik St. Georg
π©πͺHamburg, Germany
Onze Lieve Vrouwe Gasthuis
π³π±Amsterdam, Netherlands
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
π΅π±Warsaw, Poland
Medizinische Hochschule Hannover
π©πͺHannover, Germany
Staedtisches Klinikum Karlsruhe gGmbH
π©πͺKarlsruhe, Germany
Medizinische Universitaetsklinik und Poliklinik
π©πͺHeidelberg, Germany
Evangelische Krankenhaus Hamm
π©πͺHamm, Germany
Universitair Medisch Centrum St. Radboud - Nijmegen
π³π±Nijmegen, Netherlands
UniversitaetsSpital Zuerich
π¨πZurich, Switzerland
Institut Jules Bordet
π§πͺBrussels, Belgium
Krankenhaus Muenchen Schwabing
π©πͺMunich, Germany
Rigshospitalet - Copenhagen University Hospital
π©π°Copenhagen, Denmark
St. Bernward Krankenhaus
π©πͺHildeshem, Germany
Universitaetsklinikum Hamburg-Eppendorf
π©πͺHamburg, Germany
Krankenhaus Siloah - Medizinische Klinik II
π©πͺHannover, Germany
Clinic for Bone Marrow Transplantation and Hematology and Oncology
π©πͺIdar-Oberstein, Germany
Klinikum der Friedrich-Schiller Universitaet Jena
π©πͺJena, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
π©πͺLuebeck, Germany
Klinikum Rechts Der Isar - Technische Universitaet Muenchen
π©πͺMunich, Germany
Diakonie Klinikum Stuttgart
π©πͺStuttgart, Germany
Algemeen Ziekenhuis Sint Lucas
π§πͺGhent, Belgium
Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
π³π±Amsterdam, Netherlands
Hospitais da Universidade de Coimbra (HUC)
π΅πΉCoimbra, Portugal
Leiden University Medical Center
π³π±Leiden, Netherlands
Maxima Medisch Centrum - Veldhoven
π³π±Veldhoven, Netherlands