Combination Chemotherapy and Peripheral Stem Cell Transplant in Treating Patients With Relapsed Hodgkin's Lymphoma

Phase 3
Conditions
Registration Number
NCT00025636
Lead Sponsor
German Hodgkin's Lymphoma Study Group
Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplant may allow the doctors to give higher doses of chemotherapy drugs and kill more cancer cells. It is not yet known which combination chemotherapy regimen given before peripheral stem cell transplant is more ef...

Detailed Description

OBJECTIVES:

* Compare the efficacy of induction chemotherapy followed by combination chemotherapy and autologous peripheral blood stem cell transplantation with or without high-dose sequential chemotherapy in terms of freedom from treatment failure in patients with relapsed Hodgkin's lymphoma.

* Compare the toxicity of these regimens in these patients.
...

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
220
Inclusion Criteria

Not provided

Read More
Exclusion Criteria

Not provided

Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Efficacy at 3 months
Toxicity at 3 months
Secondary Outcome Measures
NameTimeMethod
Complete remission at 3 months
Overall survival at 3 months
Relapse-free survival at 3 months

Trial Locations

Locations (44)

Ziekenhuis Netwerk Antwerpen Middelheim

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Antwerp, Belgium

Universitaetsklinikum Essen

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Essen, Germany

Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet

πŸ‡©πŸ‡ͺ

Greifswald, Germany

Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin

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Berlin, Germany

University Hospital Rebro

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Zagreb, Croatia

Academisch Ziekenhuis Maastricht

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Maastricht, Netherlands

Medizinische Universitaetsklinik I at the University of Cologne

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Cologne, Germany

Universitair Ziekenhuis Antwerpen

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Edegem, Belgium

University Medical Center Groningen

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Groningen, Netherlands

Evangelisches Krankenhaus Essen Werden

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Essen, Germany

Martin Luther Universitaet

πŸ‡©πŸ‡ͺ

Halle, Germany

Universitaetsklinikum des Saarlandes

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Homburg, Germany

Charite - Campus Charite Mitte

πŸ‡©πŸ‡ͺ

Berlin, Germany

Charite - Campus Virchow Klinikum

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Berlin, Germany

Medizinische Poliklinik

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Bonn, Germany

Staedtisches Klinikum Dessau

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Dessau, Germany

Klinikum der Universitaet Muenchen - Grosshadern Campus

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Munich, Germany

Academisch Medisch Centrum at University of Amsterdam

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Amsterdam, Netherlands

Dr. Horst-Schmidt-Kliniken

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Wiesbaden, Germany

Asklepios Klinik St. Georg

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Hamburg, Germany

Onze Lieve Vrouwe Gasthuis

πŸ‡³πŸ‡±

Amsterdam, Netherlands

Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology

πŸ‡΅πŸ‡±

Warsaw, Poland

Medizinische Hochschule Hannover

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Hannover, Germany

Staedtisches Klinikum Karlsruhe gGmbH

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Karlsruhe, Germany

Medizinische Universitaetsklinik und Poliklinik

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Heidelberg, Germany

Evangelische Krankenhaus Hamm

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Hamm, Germany

Universitair Medisch Centrum St. Radboud - Nijmegen

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Nijmegen, Netherlands

UniversitaetsSpital Zuerich

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Zurich, Switzerland

Institut Jules Bordet

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Brussels, Belgium

Krankenhaus Muenchen Schwabing

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Munich, Germany

Rigshospitalet - Copenhagen University Hospital

πŸ‡©πŸ‡°

Copenhagen, Denmark

St. Bernward Krankenhaus

πŸ‡©πŸ‡ͺ

Hildeshem, Germany

Universitaetsklinikum Hamburg-Eppendorf

πŸ‡©πŸ‡ͺ

Hamburg, Germany

Krankenhaus Siloah - Medizinische Klinik II

πŸ‡©πŸ‡ͺ

Hannover, Germany

Clinic for Bone Marrow Transplantation and Hematology and Oncology

πŸ‡©πŸ‡ͺ

Idar-Oberstein, Germany

Klinikum der Friedrich-Schiller Universitaet Jena

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Jena, Germany

Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

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Luebeck, Germany

Klinikum Rechts Der Isar - Technische Universitaet Muenchen

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Munich, Germany

Diakonie Klinikum Stuttgart

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Stuttgart, Germany

Algemeen Ziekenhuis Sint Lucas

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Ghent, Belgium

Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital

πŸ‡³πŸ‡±

Amsterdam, Netherlands

Hospitais da Universidade de Coimbra (HUC)

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Coimbra, Portugal

Leiden University Medical Center

πŸ‡³πŸ‡±

Leiden, Netherlands

Maxima Medisch Centrum - Veldhoven

πŸ‡³πŸ‡±

Veldhoven, Netherlands

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