Risk Factors of ICU-acquired Weakness

• Conditions: ICU Acquired Weakness

• Registration Number: NCT04932330
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a Medical Research Council (MRC) sum score \< 48 out of a maximal score of 60. We divided patients to ICU-acquired weakness group and no ICU-acquired weakness group and compared their clinical characteristics. Baseline characteristics and therapy details were collected from the case report forms and inspection reports. Univariable analysis and logistic regression analysis were used to analyze clinical characteristics of individuals and to find risk factors of ICU-AW.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-01
• Primary Completion: 2020-03-01
• Status Verified: 2021-06
• Study First Submitted: 2021-06-01
• Study First Submitted QC: 2021-06-11
• Last Update Submitted: 2021-06-11
• Study First Posted: 2021-06-21
• Last Update Posted: 2021-06-21
• Study Completion: 2022-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

• Critical ill patients who used extracorporeal membrane oxygenation during their ICU stay. Patients were recruited from the general ICU of the second affiliated hospital of Zhejiang University, between March 2017 to March 2020.

Exclusion Criteria

• Patients who was less than 18 years old, had been proven or suspected neurological impairment, using extracorporeal membrane oxygenation less than 24 hours, severe head or spinal cord injury and pregnant woman.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences between ICU-acquired weakness in patients receiving extracorporeal membrane oxygenation support	1 day	We compared the clinical characteristics between ICU-acquired weakness group and no ICU-acquired weakness group by univariate analysis . Then we used logistic regression analysis and found out differences of ICU-acquired weakness.

Secondary Outcome Measures

Name	Time	Method
Frequency of ICU-acquired weakness in in patients receiving extracorporeal membrane oxygenation support	1 day	We calculated the prevalence of ICU-acquired weakness on the patients included in our research.

Trial Locations

Locations (1)

Xinyi Chen; 🇨🇳 Hangzhou, Please Select, China