IL-39 & IL-35 Gingival Crevicular Fluid Levels in Diabetic Patients With Generalized Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 57
- 试验地点
- 2
- 主要终点
- GCF levels of IL-39 & IL35
研究概览
简要总结
The sudy was aiming to assess and compare GCF levels of IL-39 & IL-35 in gingival crevicular fluid and to correlate the relationship between different patient groups before and after non-surgical therapy.
详细描述
Methodology:
Group I (Periodontitis Group): 19 patients suffering from generalized periodontitis with T2DM age range, 35-50 years.
Group II (Periodontitis Group): 19 patients suffering from generalized periodontitis & systemically healthy, age range: 35-50 years.
Group III (Control group): 19 Periodontally and systemically healthy volunteers who served as control subjects age range: 30-45 years.
Periodontitis participants will be collected from the outpatient clinic of oral medicine and periodontology departments in Fayoum, Beni-Swief and Ahram-Candian universities. The periodontitis included subjects will be diagnosed according to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Tonetti, MS, Greenwell, H, Kornman, KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol.; 89( Suppl 1): S159- S172, 2018.)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Stage III Grade C Generalized periodontitis with diabetes Stage III grade B Generalized periodontitis in systemic healthy subjects
排除标准
- •Patients treated with any type of medications and/ or antibiotics during the past 3 months,
- •Receiving professional periodontal treatment during the past 6 months
- •Current or former smokers
研究组 & 干预措施
Systemically healthy periodontitis
Non Surgical Periodontal therapy ( Scaling & Root planning)
干预措施: Scaling & root planning (Procedure)
Diabetic & Periodontitis
Non surgical periodontal therapy ( scaling & root planning)
干预措施: Scaling & root planning (Procedure)
Control
Healthy group with neither Diabetes nor Periodontitis
结局指标
主要结局
GCF levels of IL-39 & IL35
时间窗: 3 months
Gingival crevicular fluid levels of IL-39 \& IL-35 in healthy \& diabetic patients with periodontitis
Effect of SRP on GCF levels of IL-39 & IL35
时间窗: 3 MONTHS
Gingival crevicular fluid levels of IL-39 \& IL-35 in healthy \& diabetic patients with periodontitis after Scaling \& root planning
次要结局
未报告次要终点
研究者
Sandy Hassan
Associate professor oral medicine & periodontology departement
Fayoum University