MedPath

S0205 Gemcitabine w/ or w/o Cetuximab as First-Line Therapy in Locally Advanced Pancreas Cancer

Phase 3
Completed
Conditions
Pancreatic Cancer
Interventions
Biological: cetuximab
Registration Number
NCT00075686
Lead Sponsor
SWOG Cancer Research Network
Brief Summary

RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as cetuximab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether gemcitabine is more effective with or without cetuximab in treating pancreatic cancer.

PURPOSE: This randomized phase III trial is studying giving gemcitabine together with cetuximab to see how well it works compared to giving gemcitabine alone as first-line therapy in treating patients with locally advanced unresectable or metastatic adenocarcinoma of the pancreas.

Detailed Description

OBJECTIVES:

* Compare the overall survival of patients with locally advanced unresectable or metastatic adenocarcinoma of the pancreas treated with gemcitabine and cetuximab vs gemcitabine alone.

* Compare the time to treatment failure in patients treated with these regimens.

* Estimate the percentage of patients with epidermal growth factor receptor (EGFR) tumor expression in patients treated with these regimens.

* Compare the overall survival of patients in the EGFR-positive subset treated with these regimens.

* Compare the toxicity of these regimens in these patients.

* Compare the total response rate (confirmed and unconfirmed complete and partial response) in patients with measurable disease treated with these regimens.

* Compare the patient report of pain and quality of life of patients treated with these regimens.

OUTLINE: This is an open-label, randomized, multicenter study. Patients are stratified according to disease status (locally advanced unresectable vs metastatic), Zubrod performance status (0 or 1 vs 2), and prior pancreatectomy (yes vs no). Patients are randomized to 1 of 2 treatment arms.

* Arm I: Patients receive cetuximab IV over 1-2 hours on days 1, 8, 15, and 22 and gemcitabine IV over 30 minutes on days 1, 8, 15, and 22 for course 1 and days 1, 8, and 15 for all subsequent courses.

* Arm II: Patients receive gemcitabine as in arm I. In both arms, courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.

Quality of life is assessed at baseline, before each course, and at the end of study therapy.

Patients are followed every 6 months for 2 years and then annually for 1 year.

PROJECTED ACCRUAL: A total of 704 patients (352 per treatment arm) will be accrued for this study within 5 years.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
766
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
gemcitabine hydrochloride + IMC-C225gemcitabine hydrochlorideLoading dose: gemcitabine hydrochloride 1000mg/m2, IV on Day 1; Cetuxiumab 400mg/m2, IV on Day 1 (cycle 1 only) Weekly maintenance: Cetuximab 250mg/m2, IV on Days 8,15,22 of cycle 1 \& days 1,8,15,22 of all subsequent cycles; gemcitabine hydrochloride 1000mg/m2, IV on Days 8,15,22 of cycle 1 and Days 1,8,15 of all subsequent cycles.
gemcitabine hydrochloride alonegemcitabine hydrochloridegemcitabine hydrochloride 1000mg/m2, IV on Days 1,8,15,22 of cycle 1 and Days 1,8,15 of all subsequent cycles.
gemcitabine hydrochloride + IMC-C225cetuximabLoading dose: gemcitabine hydrochloride 1000mg/m2, IV on Day 1; Cetuxiumab 400mg/m2, IV on Day 1 (cycle 1 only) Weekly maintenance: Cetuximab 250mg/m2, IV on Days 8,15,22 of cycle 1 \& days 1,8,15,22 of all subsequent cycles; gemcitabine hydrochloride 1000mg/m2, IV on Days 8,15,22 of cycle 1 and Days 1,8,15 of all subsequent cycles.
Primary Outcome Measures
NameTimeMethod
Overall survival comparison between treatment groupsevery 4 weeks for 3 years
Secondary Outcome Measures
NameTimeMethod
Toxicity profile comparison of patients treated with 2 regimens and measured until 30 days after completion of study treatmentevery 4 weeks while on treatment
Total response rate comparison between treatment groups in the subset of patients with measurable disease by RECIST at every other courseevery 9 weeks until progression
Pain and quality of life comparison between treatment groups as measured by patient questionnaire at baseline, before each course, and then completion of study treatmentevery 4 weeks while on treatment
Response rate comparison between treatment groups as measured by RECIST and radiological evaluation at every other courseevery 9 weeks until progression
Time to treatment failure comparison between groups from registration to first observation of progressive disease, symptomatic deterioration, or deathevery 4 weeks while on treatment
Percentage of patients with EGFR tumor expression and compare overall survival of patients in the EGFR subsetevery 4 weeks for 3 years

Trial Locations

Locations (387)

Cancer Center at Providence Alaska Medical Center

🇺🇸

Anchorage, Alaska, United States

Banner Thunderbird Medical Center

🇺🇸

Glendale, Arizona, United States

CCOP - Western Regional, Arizona

🇺🇸

Phoenix, Arizona, United States

Sletten Regional Cancer Institute

🇺🇸

Great Falls, Montana, United States

St. Peter's Hospital

🇺🇸

Helena, Montana, United States

Kalispell Medical Oncology

🇺🇸

Kalispell, Montana, United States

Eastern Montana Cancer Center

🇺🇸

Miles City, Montana, United States

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

🇺🇸

Kingsport, Tennessee, United States

Southwestern Vermont Regional Cancer Center

🇺🇸

Bennington, Vermont, United States

Euclid Hospital

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Taussig Cancer Center

🇺🇸

Cleveland, Ohio, United States

United Hospital Center

🇺🇸

Clarksburg, West Virginia, United States

St. Joseph's Health Centre - Toronto

🇨🇦

Toronto, Ontario, Canada

M.D. Anderson Cancer Center at University of Texas

🇺🇸

Houston, Texas, United States

Baylor University Medical Center - Houston

🇺🇸

Houston, Texas, United States

Fred Hutchinson Cancer Research Center

🇺🇸

Seattle, Washington, United States

Harborview Medical Center

🇺🇸

Seattle, Washington, United States

Charles M. Barrett Cancer Center at University Hospital

🇺🇸

Cincinnati, Ohio, United States

LDS Hospital

🇺🇸

Salt Lake City, Utah, United States

East Alabama Medical Center

🇺🇸

Opelika, Alabama, United States

Mobile Infirmary Medical Center

🇺🇸

Mobile, Alabama, United States

Alaska Regional Hospital Cancer Center

🇺🇸

Anchorage, Alaska, United States

Highlands Oncology Group - Springdale

🇺🇸

Springdale, Arkansas, United States

Alta Bates Comprehensive Cancer Center

🇺🇸

Berkeley, California, United States

Mount Diablo Regional Cancer Center

🇺🇸

Concord, California, United States

City of Hope Comprehensive Cancer Center

🇺🇸

Duarte, California, United States

Peninsula Medical Center

🇺🇸

Burlingame, California, United States

Hembree Mercy Cancer Center at St. Edward Mercy Medical Center

🇺🇸

Ft. Smith, Arkansas, United States

California Cancer Center - Woodward Park Office

🇺🇸

Fresno, California, United States

Virginia K. Crosson Cancer Center at St. Jude Medical Center

🇺🇸

Fullerton, California, United States

Marin Cancer Institute at Marin General Hospital

🇺🇸

Greenbrae, California, United States

Sutter Health Western Division Cancer Research Group

🇺🇸

Greenbrae, California, United States

Saint Rose Hospital

🇺🇸

Hayward, California, United States

Loma Linda University Cancer Institute at Loma Linda University Medical Center

🇺🇸

Loma Linda, California, United States

Highland General Hospital at St. George's University School of Medicine

🇺🇸

Oakland, California, United States

CCOP - Bay Area Tumor Institute

🇺🇸

Oakland, California, United States

Summit Medical Center

🇺🇸

Oakland, California, United States

Valley Care Medical Center

🇺🇸

Pleasanton, California, United States

J.C. Robinson, M.D. Regional Cancer Center

🇺🇸

San Pablo, California, United States

Sutter Solano Medical Center

🇺🇸

Vallejo, California, United States

John Muir/Mt. Diablo Comprehensive Cancer Center

🇺🇸

Walnut Creek, California, United States

California Pacific Medical Center - California Campus

🇺🇸

San Francisco, California, United States

Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital

🇺🇸

Whittier, California, United States

Front Range Cancer Specialists

🇺🇸

Fort Collins, Colorado, United States

Memorial Hospital

🇺🇸

Carthage, Illinois, United States

Poudre Valley Hospital

🇺🇸

Fort Collins, Colorado, United States

North Colorado Medical Center

🇺🇸

Greeley, Colorado, United States

McKee Medical Center

🇺🇸

Loveland, Colorado, United States

Montrose Memorial Hospital Cancer Center

🇺🇸

Montrose, Colorado, United States

Exempla Lutheran Medical Center

🇺🇸

Wheat Ridge, Colorado, United States

Carl and Dorothy Bennett Cancer Center at Stamford Hospital

🇺🇸

Stamford, Connecticut, United States

Praxair Cancer Center at Danbury Hospital

🇺🇸

Danbury, Connecticut, United States

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

🇺🇸

Washington, District of Columbia, United States

Sibley Memorial Hospital

🇺🇸

Washington, District of Columbia, United States

Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center

🇺🇸

Boca Raton, Florida, United States

Halifax Medical Center

🇺🇸

Daytona Beach, Florida, United States

University of Florida Shands Cancer Center

🇺🇸

Gainesville, Florida, United States

Florida Oncology Associates

🇺🇸

Orange Park, Florida, United States

Broward General Medical Center Cancer Center

🇺🇸

Ft. Lauderdale, Florida, United States

West Florida Cancer Institute at West Florida Hospital - Pensacola

🇺🇸

Pensacola, Florida, United States

Medical Center of Central Georgia

🇺🇸

Macon, Georgia, United States

Northeast Georgia Medical Center

🇺🇸

Gainesville, Georgia, United States

John B. Amos Community Cancer Center

🇺🇸

Columbus, Georgia, United States

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

🇺🇸

Savannah, Georgia, United States

Pearlman Comprehensive Cancer Center at South Georgia Medical Center

🇺🇸

Valdosta, Georgia, United States

Saint Anthony's Hospital at Saint Anthony's Health Center

🇺🇸

Alton, Illinois, United States

St. Luke's Mountain States Tumor Institute - Boise

🇺🇸

Boise, Idaho, United States

Rush-Copley Cancer Care Center

🇺🇸

Aurora, Illinois, United States

St. Joseph Medical Center

🇺🇸

Bloomington, Illinois, United States

Decatur Memorial Hospital Cancer Care Institute

🇺🇸

Decatur, Illinois, United States

Eureka Community Hospital

🇺🇸

Eureka, Illinois, United States

Sherman Hospital

🇺🇸

Elgin, Illinois, United States

Galesburg Clinic

🇺🇸

Galesburg, Illinois, United States

Hinsdale Hematology Oncology Associates

🇺🇸

Hinsdale, Illinois, United States

Galesburg Cottage Hospital

🇺🇸

Galesburg, Illinois, United States

Medical and Surgical Specialists, L L C

🇺🇸

Galesburg, Illinois, United States

Delnor Community Hospital - Geneva

🇺🇸

Geneva, Illinois, United States

InterCommunity Cancer Center of Western Illinois

🇺🇸

Galesburg, Illinois, United States

Mason District Hospital

🇺🇸

Havana, Illinois, United States

Hopedale Medical Complex

🇺🇸

Hopedale, Illinois, United States

McDonough District Hospital

🇺🇸

Macomb, Illinois, United States

Joliet Oncology Hematology Associates, Limited - West

🇺🇸

Joliet, Illinois, United States

La Grange Memorial Hospital

🇺🇸

La Grange, Illinois, United States

Kewanee Hospital

🇺🇸

Kewanee, Illinois, United States

OSF St. Francis Medical Center

🇺🇸

Peoria, Illinois, United States

Regional Cancer Center at Memorial Medical Center

🇺🇸

Springfield, Illinois, United States

Valley Cancer Center

🇺🇸

Spring Valley, Illinois, United States

St. Francis Hospital and Health Centers - Beech Grove Campus

🇺🇸

Beech Grove, Indiana, United States

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

🇺🇸

Kansas City, Kansas, United States

Cancer Care at Our Lady of Bellefonte Hospital

🇺🇸

Ashland, Kentucky, United States

Central Baptist Hospital

🇺🇸

Lexington, Kentucky, United States

Cancer Treatment Center at Christus Schumpert St. Mary Place

🇺🇸

Shreveport, Louisiana, United States

Mercy Hospital

🇺🇸

Portland, Maine, United States

Cancer Research Center at Boston Medical Center

🇺🇸

Boston, Massachusetts, United States

Caritas Holy Family Hospital

🇺🇸

Methuen, Massachusetts, United States

Caritas Norwood Hospital

🇺🇸

Norwood, Massachusetts, United States

Hickman Cancer Center at Bixby Medical Center

🇺🇸

Adrian, Michigan, United States

Mecosta County Medical Center

🇺🇸

Big Rapids, Michigan, United States

CCOP - Grand Rapids

🇺🇸

Grand Rapids, Michigan, United States

Lacks Cancer Center at Saint Mary's Mercy Medical Center

🇺🇸

Grand Rapids, Michigan, United States

Spectrum Health Cancer Care - Butterworth Campus

🇺🇸

Grand Rapids, Michigan, United States

Holland Community Hospital

🇺🇸

Holland, Michigan, United States

Community Cancer Center of Monroe

🇺🇸

Monroe, Michigan, United States

CCOP - Metro-Minnesota

🇺🇸

Saint Louis Park, Minnesota, United States

Virginia Piper Cancer Institute at Abbott-Northwestern Hospital

🇺🇸

Minneapolis, Minnesota, United States

Toledo Hospital

🇺🇸

Toledo, Ohio, United States

UVMC Cancer Care Center at Upper Valley Medical Center

🇺🇸

Troy, Ohio, United States

Fulton County Health Center

🇺🇸

Wauseon, Ohio, United States

Tod Children's Hospital - Forum Health

🇺🇸

Youngstown, Ohio, United States

Easton Regional Cancer Center at Easton Hospital

🇺🇸

Easton, Pennsylvania, United States

McLeod Regional Medical Center

🇺🇸

Florence, South Carolina, United States

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

🇺🇸

Spartanburg, South Carolina, United States

American Fork Hospital

🇺🇸

American Fork, Utah, United States

Medical City Dallas Hospital

🇺🇸

Dallas, Texas, United States

Wilford Hall Medical Center

🇺🇸

Lackland AFB, Texas, United States

Presbyterian Hospital of Dallas

🇺🇸

Dallas, Texas, United States

Providence Centralia Hospital Regional Cancer Center

🇺🇸

Centralia, Washington, United States

University Cancer Center at University of Washington Medical Center

🇺🇸

Seattle, Washington, United States

St. Francis Hospital

🇺🇸

Federal Way, Washington, United States

Allenmore Hospital

🇺🇸

Tacoma, Washington, United States

St. Joseph Medical Center at Franciscan Health System

🇺🇸

Tacoma, Washington, United States

Providence Cancer Center at Holy Family Hospital

🇺🇸

Spokane, Washington, United States

Southwest Washington Medical Center Cancer Center

🇺🇸

Vancouver, Washington, United States

Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital

🇺🇸

Parkersburg, West Virginia, United States

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center

🇺🇸

La Crosse, Wisconsin, United States

Cancer Center of Kansas, P.A. - Winfield

🇺🇸

Winfield, Kansas, United States

Associates in Womens Health, P.A. - North Review

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas, P.A. - Chanute

🇺🇸

Chanute, Kansas, United States

Via Christi Cancer Center at Via Christi Regional Medical Center

🇺🇸

Wichita, Kansas, United States

St. Francis Comprehensive Cancer Center

🇺🇸

Topeka, Kansas, United States

CCOP - Wichita

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas, P.A. - Parsons

🇺🇸

Parsons, Kansas, United States

Mount Carmel Regional Cancer Center

🇺🇸

Pittsburg, Kansas, United States

Graham Hospital

🇺🇸

Canton, Illinois, United States

Banner Good Samaritan Medical Center

🇺🇸

Phoenix, Arizona, United States

Veterans Affairs Medical Center - Denver

🇺🇸

Denver, Colorado, United States

Barbara Ann Karmanos Cancer Institute

🇺🇸

Detroit, Michigan, United States

CCOP - Columbia River Oncology Program

🇺🇸

Portland, Oregon, United States

Institute of Oncology at Vilnius University

🇺🇸

Portland, Oregon, United States

University of Colorado Cancer Center at University of Colorado Health Sciences Center

🇺🇸

Aurora, Colorado, United States

Methodist Cancer Center at Methodist Hospital - Omaha

🇺🇸

Omaha, Nebraska, United States

Perry Memorial Hospital

🇺🇸

Princeton, Illinois, United States

BroMenn Regional Medical Center

🇺🇸

Normal, Illinois, United States

Community Hospital of Ottawa

🇺🇸

Ottawa, Illinois, United States

Illinois Valley Community Hospital

🇺🇸

Peru, Illinois, United States

Good Samaritan Regional Health Center

🇺🇸

Mt. Vernon, Illinois, United States

Oncology Hematology Associates of Central Illinois - Ottawa

🇺🇸

Ottawa, Illinois, United States

Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields

🇺🇸

Olympia Fields, Illinois, United States

Proctor Hospital

🇺🇸

Peoria, Illinois, United States

CCOP - Illinois Oncology Research Association

🇺🇸

Peoria, Illinois, United States

Cancer Treatment Center at Pekin Hospital

🇺🇸

Pekin, Illinois, United States

Reid Hospital & Health Care Services, Incorporated

🇺🇸

Richmond, Indiana, United States

Cedar Rapids Oncology Associates

🇺🇸

Cedar Rapids, Iowa, United States

Stormont-Vail Cancer Center

🇺🇸

Topeka, Kansas, United States

Sturdy Memorial Hospital

🇺🇸

Attleboro, Massachusetts, United States

Fort Wayne Medical Oncology and Hematology

🇺🇸

Fort Wayne, Indiana, United States

St. Luke's Hospital

🇺🇸

Maumee, Ohio, United States

McFarland Clinic, P. C.

🇺🇸

Ames, Iowa, United States

Genesis Regional Cancer Center at Genesis Medical Center

🇺🇸

Davenport, Iowa, United States

Cancer Center of Kansas, P.A. - Kingman

🇺🇸

Kingman, Kansas, United States

Cancer Center of Kansas, P.A. - Salina

🇺🇸

Salina, Kansas, United States

Siouxland Hematology-Oncology Associates at June E. Nylen Cancer Center

🇺🇸

Sioux City, Iowa, United States

Cancer Center of Kansas, P.A. - Dodge City

🇺🇸

Dodge City, Kansas, United States

Cancer Center of Kansas, P.A. - El Dorado

🇺🇸

El Dorado, Kansas, United States

Hematology Oncology Associates of the Quad Cities

🇺🇸

Bettendorf, Iowa, United States

Cedar Valley Medical Specialists, P.C. - West Ridgeway Avenue

🇺🇸

Waterloo, Iowa, United States

Cancer Center of Kansas, P.A. - Newton

🇺🇸

Newton, Kansas, United States

Cancer Center of Kansas, P.A. - Wichita

🇺🇸

Wichita, Kansas, United States

St. Anthony's Cancer Center

🇺🇸

St. Louis, Missouri, United States

Southwest Medical Center

🇺🇸

Liberal, Kansas, United States

Northern Michigan Hospital

🇺🇸

Petoskey, Michigan, United States

United Hospital

🇺🇸

St. Paul, Minnesota, United States

Cancer Center of Kansas, P.A. - Pratt

🇺🇸

Pratt, Kansas, United States

CCOP - Cancer Research for the Ozarks

🇺🇸

Springfield, Missouri, United States

Hulston Cancer Center at Cox Medical Center South

🇺🇸

Springfield, Missouri, United States

David C. Pratt Cancer Center at St. John's Mercy

🇺🇸

Saint Louis, Missouri, United States

Mercy and Unity Cancer Center at Mercy Hospital

🇺🇸

Coon Rapids, Minnesota, United States

Cancer Center of Boston - Chestnut Hill

🇺🇸

Boston, Massachusetts, United States

Caritas St. Elizabeth's Medical Center

🇺🇸

Boston, Massachusetts, United States

Josephine Ford Cancer Center at Henry Ford Hospital

🇺🇸

Detroit, Michigan, United States

University of Michigan Comprehensive Cancer Center

🇺🇸

Ann Arbor, Michigan, United States

Cancer Center of Kansas, P.A. - Medical Arts Tower

🇺🇸

Wichita, Kansas, United States

Battle Creek Health System Cancer Care Center

🇺🇸

Battle Creek, Michigan, United States

Central Maine Medical Center

🇺🇸

Lewiston, Maine, United States

Haematology-Oncology Associates of Ohio and Michigan, P.C.

🇺🇸

Lambertville, Michigan, United States

West Michigan Cancer Center

🇺🇸

Kalamazoo, Michigan, United States

Munson Medical Center

🇺🇸

Traverse City, Michigan, United States

William Beaumont Hospital - Royal Oak Campus

🇺🇸

Royal Oak, Michigan, United States

Bronson Methodist Hospital

🇺🇸

Kalamazoo, Michigan, United States

Metropolitan Hospital

🇺🇸

Grand Rapids, Michigan, United States

Borgess Medical Center

🇺🇸

Kalamazooaa, Michigan, United States

Mercy Memorial Hospital System

🇺🇸

Monroe, Michigan, United States

Hackley Hospital

🇺🇸

Muskegon, Michigan, United States

Fairview Ridges Hospital

🇺🇸

Burnsville, Minnesota, United States

MidMichigan Medical Center - Midland

🇺🇸

Midland, Michigan, United States

Upper Michigan Cancer Center at Marquette General Hospital

🇺🇸

Marquette, Michigan, United States

Community Medical Center

🇺🇸

Missoula, Montana, United States

Fairview Southdale Hospital

🇺🇸

Edina, Minnesota, United States

Internal Medicine Associates of Bozeman

🇺🇸

Bozeman, Montana, United States

Glacier Oncology, PLLC

🇺🇸

Kalispell, Montana, United States

Roswell Park Cancer Institute

🇺🇸

Buffalo, New York, United States

CCOP - Montana Cancer Consortium

🇺🇸

Billings, Montana, United States

Deaconess Billings Clinic Cancer Center

🇺🇸

Billings, Montana, United States

Deaconess Billings Clinic - Downtown

🇺🇸

Billings, Montana, United States

Good Samaritan Health Systems

🇺🇸

Kearney, Nebraska, United States

University of Mississippi Medical Center

🇺🇸

Jackson, Mississippi, United States

Keesler Medical Center - Keesler Air Force Base

🇺🇸

Kessler AFB, Mississippi, United States

Northern Rockies Radiation Oncology Center

🇺🇸

Billings, Montana, United States

Mercy and Unity Cancer Center at Unity Hospital

🇺🇸

Fridley, Minnesota, United States

Ridgeview Medical Center

🇺🇸

Waconia, Minnesota, United States

Bozeman Deaconess Hospital

🇺🇸

Bozeman, Montana, United States

Hubert H. Humphrey Cancer Center at North Memorial Medical Center

🇺🇸

Robbinsdale, Minnesota, United States

Hematology-Oncology Centers of the Northern Rockies - Billings

🇺🇸

Billings, Montana, United States

Big Sky Oncology

🇺🇸

Great Falls, Montana, United States

Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital

🇺🇸

Gape Girardeau, Missouri, United States

Park Nicollet Health Services

🇺🇸

St. Louis Park, Minnesota, United States

CCOP - St. Louis-Cape Girardeau

🇺🇸

St. Louis, Missouri, United States

St. James Community Hospital

🇺🇸

Butte, Montana, United States

Kalispell Regional Medical Center

🇺🇸

Kalispell, Montana, United States

New York Oncology Hematology, PC - Albany

🇺🇸

Albany, New York, United States

Valley Hospital - Ridgewood

🇺🇸

Ridgewood, New Jersey, United States

University of New Mexico Cancer Research and Treatment Center

🇺🇸

Albuquerque, New Mexico, United States

Wayne Memorial Hospital, Incorporated

🇺🇸

Goldsboro, North Carolina, United States

Montana Cancer Specialists at Montana Cancer Center

🇺🇸

Missoula, Montana, United States

Pardee Memorial Hospital

🇺🇸

Hendersonville, North Carolina, United States

New York Oncology Hematology, P.C.

🇺🇸

Latham, New York, United States

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

🇺🇸

Missoula, Montana, United States

Grant Riverside Cancer Services

🇺🇸

Columbus, Ohio, United States

Doctors Hospital at Ohio Health

🇺🇸

Columbus, Ohio, United States

Long Island Jewish Medical Center

🇺🇸

New Hyde Park, New York, United States

Seacoast Cancer Center at Wentworth-Douglass Hospital

🇺🇸

Dover, New Hampshire, United States

CCOP - North Shore University Hospital

🇺🇸

Manhasset, New York, United States

Adirondack Cancer Care - Glens Falls

🇺🇸

Glens Falls, New York, United States

Faxton Regional Cancer Center

🇺🇸

Utica, New York, United States

San Juan Regional Cancer Center

🇺🇸

Farmington, New Mexico, United States

CCOP - Hematology-Oncology Associates of Central New York

🇺🇸

Syracuse, New York, United States

Presbyterian Cancer Center at Presbyterian Hospital

🇺🇸

Charlotte, North Carolina, United States

Randolph Hospital

🇺🇸

Asheboro, North Carolina, United States

Lenoir Memorial Cancer Center

🇺🇸

Kinston, North Carolina, United States

John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital

🇺🇸

Eden, North Carolina, United States

Wayne Radiation Oncology

🇺🇸

Goldsboro, North Carolina, United States

Iredell Memorial Hospital

🇺🇸

Statesville, North Carolina, United States

Akron City Hospital

🇺🇸

Akron, Ohio, United States

Moses Cone Regional Cancer Center at Wesley Long Community Hospital

🇺🇸

Greensboro, North Carolina, United States

McDowell Cancer Center at Akron General Medical Center

🇺🇸

Akron, Ohio, United States

Grandview Hospital

🇺🇸

Dayton, Ohio, United States

Wood County Oncology Center

🇺🇸

Bowling Green, Ohio, United States

University Hospitals Ireland Cancer Center at Mercy Medical Center

🇺🇸

Canton, Ohio, United States

Kenton Oncology, Incorporated

🇺🇸

Kenton, Ohio, United States

Adena Regional Medical Center

🇺🇸

Chillicothe, Ohio, United States

CCOP - Columbus

🇺🇸

Columbus, Ohio, United States

Mount Carmel West Hospital

🇺🇸

Columbus, Ohio, United States

Huron Hospital Cancer Care Center

🇺🇸

Cleveland, Ohio, United States

McKay-Dee Hospital Center

🇺🇸

Ogden, Utah, United States

Veterans Affairs Medical Center - Dayton

🇺🇸

Dayton, Ohio, United States

Grady Memorial Hospital

🇺🇸

Delaware, Ohio, United States

Utah Valley Regional Medical Center - Provo

🇺🇸

Provo, Utah, United States

Charles F. Kettering Memorial Hospital

🇺🇸

Kettering, Ohio, United States

Northwest Ohio Oncology Center

🇺🇸

Maumee, Ohio, United States

Blanchard Valley Medical Associates

🇺🇸

Findlay, Ohio, United States

Community Oncology Group at Cleveland Clinic Cancer Center

🇺🇸

Independence, Ohio, United States

Fremont Memorial Hospital

🇺🇸

Fremont, Ohio, United States

St. Rita's Medical Center

🇺🇸

Lima, Ohio, United States

Hillcrest Cancer Center at Hillcrest Hospital

🇺🇸

Mayfield Heights, Ohio, United States

North Coast Cancer Care, Incorporated

🇺🇸

Sandusky, Ohio, United States

Mercy Medical Center

🇺🇸

Springfield, Ohio, United States

Community Hospital of Springfield and Clark County

🇺🇸

Springfield, Ohio, United States

St. Vincent Mercy Medical Center

🇺🇸

Toledo, Ohio, United States

Providence St. Vincent Medical Center

🇺🇸

Portland, Oregon, United States

South Pointe Hospital Cancer Care Center

🇺🇸

Warrensville Heights, Ohio, United States

Cleveland Clinic - Wooster

🇺🇸

Wooster, Ohio, United States

CCOP - Toledo Community Hospital

🇺🇸

Toledo, Ohio, United States

Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital

🇺🇸

Westerville, Ohio, United States

St. Charles Medical Center - Bend

🇺🇸

Bend, Oregon, United States

Legacy Mount Hood Medical Center

🇺🇸

Gresham, Oregon, United States

Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center

🇺🇸

Dubois, Pennsylvania, United States

Salem Hospital Regional Cancer Center

🇺🇸

Salem, Oregon, United States

St. Luke's Hospital Cancer Center

🇺🇸

Bethlehem, Pennsylvania, United States

Legacy Meridian Park Hospital

🇺🇸

Tualatin, Oregon, United States

Genesis - Good Samaritan Hospital

🇺🇸

Zanesville, Ohio, United States

Ruth G. McMillan Cancer Center at Greene Memorial Hospital

🇺🇸

Xenia, Ohio, United States

Utah Cancer Specialists at UCS Cancer Center

🇺🇸

Salt Lake City, Utah, United States

Medical X-Ray Center, PC

🇺🇸

Sioux Falls, South Dakota, United States

Cancer Care Northwest - Spokane South

🇺🇸

Spokane, Washington, United States

Rose Ramer Cancer Clinic at Anderson Area Medical Center

🇺🇸

Anderson, South Carolina, United States

Thompson Cancer Survival Center

🇺🇸

Knoxville, Tennessee, United States

CCOP - Upstate Carolina

🇺🇸

Spartanburg, South Carolina, United States

Olympic Hematology and Oncology

🇺🇸

Bremerton, Washington, United States

Bon Secours St. Francis Health System

🇺🇸

Greenville, South Carolina, United States

Logan Regional Hospital

🇺🇸

Logan, Utah, United States

Rockwood Clinic Cancer Treatment Center

🇺🇸

Spokane, Washington, United States

Auburn Regional Center for Cancer Care

🇺🇸

Auburn, Washington, United States

CCOP - Greenville

🇺🇸

Greenville, South Carolina, United States

Harrington Cancer Center

🇺🇸

Amarillo, Texas, United States

Dixie Regional Medical Center - East Campus

🇺🇸

Saint George, Utah, United States

Martha Jefferson Hospital Cancer Care Center

🇺🇸

Charlottesville, Virginia, United States

Sioux Valley Hospital and University of South Dakota Medical Center

🇺🇸

Sioux Falls, South Dakota, United States

Cottonwood Hospital Medical Center

🇺🇸

Murray, Utah, United States

St. Mary Regional Cancer Center

🇺🇸

Langhorne, Pennsylvania, United States

Allegheny Cancer Center at Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Avera Cancer Institute

🇺🇸

Sioux Falls, South Dakota, United States

Center for Cancer Medicine and Blood Disorders, PA

🇺🇸

El Paso, Texas, United States

St. Joseph Hospital Community Cancer Center

🇺🇸

Bellingham, Washington, United States

Luther Midlelfort Hospital

🇺🇸

Eau Claire, Wisconsin, United States

Green Mountain Oncology Group

🇺🇸

Bennington, Vermont, United States

Royal Victoria Hospital of Barrie

🇨🇦

Barrie, Ontario, Canada

Vince Lombardi Cancer Center - Elkhorn

🇺🇸

Elkhorn, Wisconsin, United States

Nova Scotia Cancer Centre

🇨🇦

Halifax, Nova Scotia, Canada

Skagit Valley Hospital Cancer Care Center

🇺🇸

Mt. Vernon, Washington, United States

Providence St. Peter Hospital Regional Cancer Center

🇺🇸

Olympia, Washington, United States

Capital Medical Center

🇺🇸

Olympia, Washington, United States

Southwest Virginia Regional Cancer Center

🇺🇸

Norton, Virginia, United States

Midelfort Clinic - Luther

🇺🇸

Eau Claire, Wisconsin, United States

Fox Valley Hematology and Oncology - East Grant Street

🇺🇸

Appleton, Wisconsin, United States

Medical Consultants, Limited

🇺🇸

Milwaukee, Wisconsin, United States

All Saints Cancer Center at All Saints Medical Center

🇺🇸

Racine, Wisconsin, United States

CCOP - Northwest

🇺🇸

Tacoma, Washington, United States

MultiCare Regional Cancer Center at Tacoma General Hospital

🇺🇸

Tacoma, Washington, United States

Welch Cancer Center at Sheridan Memorial Hospital

🇺🇸

Sheridan, Wyoming, United States

St. Clare Hospital

🇺🇸

Tacoma, Washington, United States

Wenatchee Valley Clinic

🇺🇸

Wenatchee, Washington, United States

CancerCare Manitoba

🇨🇦

Winnipeg, Manitoba, Canada

Trillium Health Centre - Mississauga Site

🇨🇦

Mississauga, Ontario, Canada

Saint John Regional Hospital

🇨🇦

Saint John, New Brunswick, Canada

Allan Blair Cancer Centre at Pasqua Hospital

🇨🇦

Regina, Saskatchewan, Canada

Mercy Regional Cancer Center at Mercy Medical Center

🇺🇸

Cedar Rapids, Iowa, United States

Genesis Medical Center - West Campus

🇺🇸

Davenport, Iowa, United States

Siouxland Regional Cancer Center

🇺🇸

Sioux City, Iowa, United States

Heartland Oncology & Hematology

🇺🇸

Council Bluffs, Iowa, United States

Mercy Medical Center - Sioux City

🇺🇸

Sioux City, Iowa, United States

Ottumwa Regional Health Center Cancer Center

🇺🇸

Ottumwa, Iowa, United States

Covenant Cancer Treatment Center

🇺🇸

Waterloo, Iowa, United States

St. Luke's Regional Medical Center

🇺🇸

Sioux City, Iowa, United States

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

🇺🇸

Orange, California, United States

Oncology/Hematology Associates of Central Illinois, P.C.

🇺🇸

Peoria, Illinois, United States

Good Samaritan Hospital

🇺🇸

Dayton, Ohio, United States

Middletown Regional Hospital

🇺🇸

Middletown, Ohio, United States

Firelands Regional Medical Center

🇺🇸

Sandusky, Ohio, United States

Promedica Cancer Center at Flower Hospital

🇺🇸

Sylvania, Ohio, United States

Medical College of Ohio Cancer Institute

🇺🇸

Toledo, Ohio, United States

United States Air Force Medical Center Wright-Patterson

🇺🇸

Wright-Patterson Afb, Ohio, United States

Brooke Army Medical Center

🇺🇸

Fort Sam Houston, Texas, United States

Reading Hospital and Medical Center

🇺🇸

Reading, Pennsylvania, United States

Jennersville Regional Hospital

🇺🇸

West Grove, Pennsylvania, United States

UMC Southwest Cancer and Research Center

🇺🇸

Lubbock, Texas, United States

Danville Regional Medical Center

🇺🇸

Danville, Virginia, United States

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

🇺🇸

Seattle, Washington, United States

North Puget Oncology at United General Hospital

🇺🇸

Sedro-Wooley, Washington, United States

Providence Cancer Center at Sacred Heart Medical Center

🇺🇸

Spokane, Washington, United States

Rutherford Hospital

🇺🇸

Rutherfordton, North Carolina, United States

University of California Davis Cancer Center

🇺🇸

Sacramento, California, United States

Mercy General Hospital

🇺🇸

Sacramento, California, United States

Forsyth Regional Cancer Center at Forsyth Medical Center

🇺🇸

Winston-Salem, North Carolina, United States

Methodist Medical Center of Illinois

🇺🇸

Peoria, Illinois, United States

Group Health Central Hospital

🇺🇸

Seattle, Washington, United States

Community Cancer Center

🇺🇸

Normal, Illinois, United States

Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center

🇺🇸

Portland, Oregon, United States

St. Joseph's Hospital Health Center - Syracuse

🇺🇸

Syracuse, New York, United States

Toledo Clinic - Oregon

🇺🇸

Oregon, Ohio, United States

Providence Cancer Center at Providence Portland Medical Center

🇺🇸

Portland, Oregon, United States

Wilson Medical Center

🇺🇸

Wilson, North Carolina, United States

St. Joseph Mercy Hospital

🇺🇸

Pontiac, Michigan, United States

Carle Cancer Center at Carle Foundation Hospital

🇺🇸

Urbana, Illinois, United States

CCOP - Carle Cancer Center

🇺🇸

Urbana, Illinois, United States

St. Margaret's Hospital

🇺🇸

Spring Valley, Illinois, United States

Saint Anthony Memorial Health Centers

🇺🇸

Michigan City, Indiana, United States

Licking Memorial Cancer Care Program at Licking Memorial Hospital

🇺🇸

Newark, Ohio, United States

St. John's Regional Health Center

🇺🇸

Springfield, Missouri, United States

Riverside Methodist Hospital Cancer Care

🇺🇸

Columbus, Ohio, United States

Toledo Clinic, Incorporated - Main Clinic

🇺🇸

Toledo, Ohio, United States

Lima Memorial Hospital

🇺🇸

Lima, Ohio, United States

Toledo Surgical Specialists

🇺🇸

Toledo, Ohio, United States

Good Samaritan Cancer Center

🇺🇸

Puyallup, Washington, United States

Annie Penn Cancer Center

🇺🇸

Reidsville, North Carolina, United States

Samaritan North Cancer Care Center

🇺🇸

Dayton, Ohio, United States

CCOP - Dayton

🇺🇸

Dayton, Ohio, United States

Mission Hospitals - Memorial Campus

🇺🇸

Asheville, North Carolina, United States

Florida Hospital Cancer Institute at Florida Hospital Orlando

🇺🇸

Orlando, Florida, United States

CCOP - Kansas City

🇺🇸

Kansas City, Missouri, United States

Roper St. Francis Cancer Center at Roper Hospital

🇺🇸

Charleston, South Carolina, United States

Hollings Cancer Center at Medical University of South Carolina

🇺🇸

Charleston, South Carolina, United States

St. Vincent Healthcare

🇺🇸

Billings, Montana, United States

Cancer Center of Kansas, P.A. - Wellington

🇺🇸

Wellington, Kansas, United States

Saint Francis Medical Center

🇺🇸

Cape Girardeau, Missouri, United States

Fairfield Medical Center

🇺🇸

Lancaster, Ohio, United States

Strecker Cancer Center at Marietta Memorial Hospital

🇺🇸

Marietta, Ohio, United States

Providence Milwaukie Hospital

🇺🇸

Milwaukie, Oregon, United States

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