Is There an Association Between Quadriceps Strength and Different Markers of Fragility in Patients With Cirrhosis?
Not Applicable
Recruiting
- Conditions
- Cirrhosis
- Interventions
- Other: Frailty assessment
- Registration Number
- NCT06133127
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
Physical frailty and malnutrition are important factors in morbidity and mortality in patients with cirrhosis. No study has assessed the validity of Liver Frailty Index (LFI) against reference measures such as maximal lower limb strength.
Main objective: To assess the association between LFI score and isometric maximal lower limb strength (quadriceps) in patients with cirrhosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
SUBJECT :
- with a diagnosis of liver cirrhosis (regardless of cirrhosis stage and etiology)
- under the care of a physician practising in the University Hospital Estaing in Clermont-Ferrand
- affiliated to the french social security system
Exclusion Criteria
SUBJECT:
- with hepatocellular carcinoma
- with HIV infection
- with hepatic encephalopathy grade ≥ 2
- with cognitive dysfunction
- with contraindication for physical activity
- with knee pain/knee disorders
- pregnant or breastfeeding
- under protective supervision (guardianship, curatorship, protection of the court)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description single group assignment Frailty assessment Same assessments for all patients.
- Primary Outcome Measures
Name Time Method Isometric quadriceps strength once, at inclusion Isometric quadriceps strength (N.m) will be assessed 3 times with 30 second rest between each try. The dominant leg of each participant will be assessed, a standardised warm-up will be conducted to have effective results.
- Secondary Outcome Measures
Name Time Method Malnutrition: Mini Nutritional Assessment (MNA)) once, at inclusion Body composition by circumference and triceps skinfold once, at inclusion Frailty by LFI once, at inclusion Frailty by Short Physical Performance Battery (SPPB) once, at inclusion Malnutrition: Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) once, at inclusion Muscle cramps by Cramp questionnaire once, at inclusion
Trial Locations
- Locations (1)
CHU clermont-ferrand
🇫🇷Clermont-Ferrand, France