Effective Treatment of Alzheimer's and Dementia With the MIND Protocol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Montreal Cognitive Assessment (MoCA)
研究概览
简要总结
Treating with measures that may improve metabolic functioning of neurons in an integrated protocol
详细描述
Most organ failure results in modest drops in function until over 50% of function is lost. At a certain point, even modest drops in physiologic activity result in dramatic drops in clinical function. Though less homogeneous than in other organs, clinical experience and the literature suggests a similar process occurs in the brain. The hypothesis is that by using an integrated protocol to, essentially, "tune up" neuronal function, a 5-10 % improvement in metabolic functioning may translate to significant improvement in clinical functioning. This tune-up will include "MIND":
M- Metabolism-- optimizing hormonal function I- Infections-- looking for and eliminating N- Nutritional and herbal support D- Drugs- Weaning subjects off unneeded medications
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A diagnosis of Alzheimer's and/or dementia with an MMSE score over 12 or being ambulatory and able to travel outside the home with assistance.
- •Must have a caregiver living with them.
排除标准
- •Overt progressive and severe causes of secondary dementia such as metastatic brain cancers, or severe overt infectious encephalopathies or severe autoimmune illness.
- •Also, severe life threatening illnesses which would make them unlikely to be alive after 6-12 months
结局指标
主要结局
Montreal Cognitive Assessment (MoCA)
时间窗: 6 months
Looking to see what percent of patients show improvement
次要结局
- Alzheimer's Disease Assessment Scale- Activities of Daily Living (ADAS-ADL)(6 months)
- Mini Mental Status Exam (MMSE)(6 months)