Treatment of Alzheimer's and Dementia With the Metabolism, Infections, Nutrition, Drug Elimination (MIND) Protocol

Not Applicable

Completed

• Conditions: Alzheimer's Disease; Dementia

• Registration Number: NCT02260167
• Lead Sponsor: Practitioners Alliance Network

Brief Summary

Treating with measures that may improve metabolic functioning of neurons in an integrated protocol

Detailed Description

Most organ failure results in modest drops in function until over 50% of function is lost. At a certain point, even modest drops in physiologic activity result in dramatic drops in clinical function. Though less homogeneous than in other organs, clinical experience and the literature suggests a similar process occurs in the brain. The hypothesis is that by using an integrated protocol to, essentially, "tune up" neuronal function, a 5-10 % improvement in metabolic functioning may translate to significant improvement in clinical functioning. This tune-up will include "MIND":

M- Metabolism-- optimizing hormonal function I- Infections-- looking for and eliminating N- Nutritional and herbal support D- Drugs- Weaning subjects off unneeded medications

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2014-10-05
• Study First Submitted QC: 2014-10-08
• Study First Posted: 2014-10-09
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-06
• Last Update Posted: 2020-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• A diagnosis of Alzheimer's and/or dementia with an MMSE score over 12 or being ambulatory and able to travel outside the home with assistance.
• Must have a caregiver living with them.

Exclusion Criteria

• Overt progressive and severe causes of secondary dementia such as metastatic brain cancers, or severe overt infectious encephalopathies or severe autoimmune illness.
• Also, severe life threatening illnesses which would make them unlikely to be alive after 6-12 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Montreal Cognitive Assessment (MoCA)	6 months	Looking to see what percent of patients show improvement

Secondary Outcome Measures

Name	Time	Method
Alzheimer's Disease Assessment Scale- Activities of Daily Living (ADAS-ADL)	6 months
Mini Mental Status Exam (MMSE)	6 months

Trial Locations

Locations (1)

PAN; 🇺🇸 Kailua, Hawaii, United States