Nasal Intermittent Positive-Pressure Ventilation for Twin Infants With Respiratory Distress Syndrome
Not Applicable
Completed
- Conditions
- Neonatal Respiratory Distress Syndrome
- Registration Number
- NCT01926106
- Lead Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Brief Summary
In the present study, we hypothesized that primary mode nIPPV initiated shortly after birth would decrease the incidence of intubation or death in twin infants when compared to nCPAP.
- Detailed Description
After inclusion of eligible twins infants,one of the twins was supported by nCPAP and another nIPPV.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 286
Inclusion Criteria
- Twins
- Clinical diagnosis of mild-moderate respiratory distress syndrome
- requiring a fraction of inspired oxigen (FiO2 ) <0.40 to keep oxygen saturation of 90%-95%
- a chest X-ray suggestive of early stage hyaline membrane disease, (i.e. mild microgranulia and air bronchogram)
Exclusion Criteria
- pneumothorax
- pneumomediastinum
- surgical diseases
- cardiac diseases
- intraventricular hemorrage
- major congenital defects
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method incidence of intubation 48h
- Secondary Outcome Measures
Name Time Method incidence of BPD 1 month
Trial Locations
- Locations (1)
Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University
🇨🇳Chongqing, Chongqing, China
Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University🇨🇳Chongqing, Chongqing, China