Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health Related Quality of Life in Patients on Hemodialysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- assessment of change of estimated glomerular filtration rate
研究概览
简要总结
this study was done to investigate the effect of intradialytic blood flow restriction training on functional capacity, estimated glomerular filtration rate and health related Quality of life in patients on Hemodialysis
详细描述
Chronic kidney disease affects 10% to 15% of the population and is characterized by a progressive decline in glomerular filtration rate. The disease can lead to frailty, muscle mass wasting, and sarcopenia, affecting functional mobility and quality-of-life measures. The increased protein catabolism in Chronic kidney disease is partly due to inflammatory status, nutrient loss during dialysis, and musculoskeletal system changes. Assessment of muscle functionality can provide additional diagnostic and prognostic information for clinical outcomes, quality of life, and mortality rates. Exercise training with blood flow restriction is a potential method for clinical musculoskeletal rehabilitation, potentially improving strength, physical function, blood pressure control, glucose homeostasis, autonomic function, renal deterioration, dialysis adequacy, and antioxidant defenses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients were
- •Both sex aged from forty to sixty years
- •Stable chronic hemodialysis patient (< 3 months)
- •Participants will be deemed medically eligible by their treating physician before participation in the present study
- •Free from any other disease could interfere with exercise
排除标准
- •Hemodynamic instability during hemodialysis over the last month
- •Neurodegenerative diseases
- •Autoimmune diseases (i.e., lupus erythematosus)
- •Surgery within the past 3 months
- •Severe arrhythmia, angina or cerebrovascular disease
- •Unstable on dialysis
- •Any musculoskeletal problem interfere with exercise
研究组 & 干预措施
blood flow restriction
Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion Pressure. training was conducted for 2 time/weak for 2 consecutive month
干预措施: conventional exercise Program (Other)
blood flow restriction
Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion Pressure. training was conducted for 2 time/weak for 2 consecutive month
干预措施: blood flow restriction training (Other)
conventional exercise Program
Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program only included isometric, aerobic, and resisted exercise individualized for every patient. training was conducted for 2 time/weak for 2 consecutive month
干预措施: conventional exercise Program (Other)
结局指标
主要结局
assessment of change of estimated glomerular filtration rate
时间窗: at baseline and after 8 weeks
Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration Creatinine Equation (2021) as recommended by the National Kidney Foundation to assess renal function and detect deterioration.
次要结局
- assessment of change of Limb Occlusion Pressure(at baseline and after 8 weeks)
- assessment of change of Glucose Homeostasis(at baseline and after 8 weeks)
- assessment of change of upper limb Muscle Strength(at baseline and after 8 weeks)
- assessment of change of lower limb Muscle Strength(at baseline and after 8 weeks)
研究者
Alaa Sayed Abd El Aziz
principal investigator
Beni-Suef University