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临床试验/NCT02440490
NCT02440490已完成不适用

Optimising Cognitive Function in Patients With Chronic Pain

Monash University1 个研究点 分布在 1 个国家目标入组 39 人开始时间: 2015年5月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
39
试验地点
1
主要终点
Subjective cognitive functioning

研究概览

简要总结

Cognitive difficulties often occur with chronic pain. The aim of this randomised controlled trial is to determine whether various aspects of cognitive function can be improved. An 8-week course of cognitive training via a web-based training program (3 times per week) will be contrasted with watching informative documentary videos (for the same length of time). Outcomes include subjective and objective measures of cognition, as well as self-report measures of mood and pain.

详细描述

Rationale for project:

Cognitive difficulties may occur with chronic pain, potentially indicative of compromised functioning in frontal brain regions, which also results in greater difficulty controlling pain, with increased rumination and worry. Discovering a successful method for strengthening these neural systems may improve cognitive skills important for daily life and maximise therapeutic outcomes.

Research questions:

In people experiencing cognitive deficits due to their pain condition:

  1. Can neurocognitive abilities be improved?
  2. Can such improvements bring about better daily functioning in general?
  3. If these training protocols improve cognition, will there also be an effect of pain reduction, i.e., in the extent to which pain interferes with a person's life?

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Chronic pain condition
  • •Access to computer and internet

排除标准

  • •High dosages of opioid or benzodiazepine medication
  • •Currently receiving active allied health treatment
  • •Intellectual disability, traumatic brain injury, dementia, or other neurological disorders

研究组 & 干预措施

Computerised cognitive training

Experimental

The cognitive training protocol will be run using pre-validated software, HappyNeuronPro, that delivers cognitive training games. The games are designed to be visually interesting and engaging, and are varied so that each session will comprise multiple different games, to avoid boredom. They begin with easy-to-follow instructions and demonstrations, then as the participant progresses, the difficulty is automatically increased in correspondence with their performance, to avoid ceiling or plateau effects. Participants will be assigned a program targeting multiple facets of cognition found to be compromised in chronic pain states, including divided attention, working memory, mentally planning a sequence of items to form a pattern or complete a puzzle, and response inhibition.

干预措施: Computerised cognitive training (Behavioral)

Video watching

Active Comparator

This group will be provided with a variety of videos to watch, the content of which will be in the style of documentaries on general interest topics such as nature, travel, culture, and history. Each video is followed by multiple-choice questions that participants will answer, to ensure attention was engaged. The videos are visually stimulating and engaging, but involve no increment in difficulty or requirement to improve skills. They may provide some distraction from pain and may be relaxing, interesting and informative.

干预措施: Video watching (Behavioral)

结局指标

主要结局

Subjective cognitive functioning

时间窗: 8 weeks

Self-report measures of cognition

Objective cognitive functioning

时间窗: 8 weeks

Composite of neuropsychological test scores

次要结局

  • Pain(8 weeks)
  • Mood and coping(8 weeks)
  • Heart rate variability(8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Katharine Baker

Katharine Baker

Monash University

研究点 (1)

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