Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: Computerized Cognitive Stimulation

• Registration Number: NCT03195803
• Lead Sponsor: Leila DJABELKHIR

Brief Summary

This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.

Detailed Description

White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.

Study Timeline

• Study Start: 2015-10
• Primary Completion: 2017-04
• Study Completion: 2017-04
• Status Verified: 2017-06
• Study First Submitted: 2017-06-14
• Study First Submitted QC: 2017-06-20
• Last Update Submitted: 2017-06-20
• Study First Posted: 2017-06-22
• Last Update Posted: 2017-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Clinical diagnosis of Mild Cognitive Impairment
• With and without white matter hyperintensities
• MRI available or accept to perform one
• No engagement in other cognitive intervention program

Exclusion Criteria

• Psychiatric and neurological disorders
• History of alcohol or other substance abuse
• Sensory and/or motor deficit affecting the use of a tablet

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MCI without WMH	Computerized Cognitive Stimulation	Computerized Cognitive Stimulation was administered to this group, twice a week.
MCI with WMH	Computerized Cognitive Stimulation	Computerized Cognitive Stimulation was administered to this group, twice a week.

Primary Outcome Measures

Name	Time	Method
Rey Auditory Verbal Learning test	Baseline assessment, change from Baseline on Rey Auditory Verbal Learning test at 3 months immediately after intervention and at 3 months follow-up	Assessment of verbal learning in episodic memory