Bowel Preparation for Left Side Colon Surgery Impact on the Intestinal Microbiome: Oral Preparation vs Enema
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Intestinal microbiome composition
研究概览
简要总结
Mechanical bowel preparation for left-sided colorectal surgery remains standard in most cases. However, there are some discrepancies on how to prepare the bowl, while rectal enema and oral agents are both available methods.
The knowledge of intestinal microbiome role on surgical outcomes is increasing, since few recent reports linked microbiome composition to postoperative complications, such as anastomotic insufficiency. Although, it is not clear how the bowel preparation affects the gut microbiome. Therefore, different bowel preparation techniques impact on gut microbiome will be studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 y.;
- •Signed informed consent;
- •Left-side colorectal resection for colorectal cancer;
排除标准
- •Anticipated ileostoma;
- •Allergy to oral preparation agents;
- •Multivisceral surgery;
- •Emergency surgery;
- •History of inflammatory bowel disease;
- •History of surgery disrupting gastrointestinal tract integrity;
- •Signs of tumor obturating the lumen of the bowel;
结局指标
主要结局
Intestinal microbiome composition
时间窗: 6 days after surgery
Significant differences in the beta-diversity of the intestinal microbiome between oral and enema groups
次要结局
- Intestinal microbiome composition(6 and 30 days after surgery)
研究者
Rimantas Bausys
Principle Investigator
Vilnius University